249293

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1025464..1026278 Replicon chromosome
Accession NZ_CP099705
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 013+

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NG892_RS04970 Protein ID WP_000971655.1
Coordinates 1025464..1025991 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NG892_RS04975 Protein ID WP_000855692.1
Coordinates 1025988..1026278 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG892_RS04950 (1020764) 1020764..1023331 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NG892_RS04955 (1023490) 1023490..1024011 + 522 WP_000858988.1 hypothetical protein -
NG892_RS04960 (1024183) 1024183..1024839 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NG892_RS04965 (1025186) 1025186..1025391 + 206 Protein_974 IS5/IS1182 family transposase -
NG892_RS04970 (1025464) 1025464..1025991 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NG892_RS04975 (1025988) 1025988..1026278 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NG892_RS04980 (1026548) 1026548..1026726 - 179 Protein_977 IS3 family transposase -
NG892_RS04985 (1026967) 1026967..1027293 + 327 WP_000393302.1 hypothetical protein -
NG892_RS04990 (1027566) 1027566..1027913 - 348 WP_001669174.1 DUF1493 family protein -
NG892_RS04995 (1027898) 1027898..1028347 - 450 WP_000381610.1 membrane protein -
NG892_RS05000 (1028778) 1028778..1029221 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NG892_RS05005 (1029678) 1029678..1030328 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1025215..1035641 10426
flank IS/Tn - - 1025215..1025391 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T249293 WP_000971655.1 NZ_CP099705:c1025991-1025464 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT249293 WP_000855692.1 NZ_CP099705:c1026278-1025988 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References