270611

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 995981..996795 Replicon chromosome
Accession NZ_CP117338
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM095

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag PQP94_RS04765 Protein ID WP_000971655.1
Coordinates 995981..996508 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag PQP94_RS04770 Protein ID WP_000855692.1
Coordinates 996505..996795 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP94_RS04745 (991281) 991281..993848 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
PQP94_RS04750 (994007) 994007..994528 + 522 WP_000858988.1 hypothetical protein -
PQP94_RS04755 (994700) 994700..995356 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQP94_RS04760 (995703) 995703..995908 + 206 Protein_933 IS5/IS1182 family transposase -
PQP94_RS04765 (995981) 995981..996508 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
PQP94_RS04770 (996505) 996505..996795 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
PQP94_RS04775 (997065) 997065..997243 - 179 Protein_936 IS3 family transposase -
PQP94_RS04780 (997484) 997484..997810 + 327 WP_000393302.1 hypothetical protein -
PQP94_RS04785 (998083) 998083..998430 - 348 WP_001669174.1 DUF1493 family protein -
PQP94_RS04790 (998415) 998415..998864 - 450 WP_000381610.1 membrane protein -
PQP94_RS04795 (999295) 999295..999738 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQP94_RS04800 (1000195) 1000195..1000845 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 995732..1006158 10426
flank IS/Tn - - 995732..995908 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T270611 WP_000971655.1 NZ_CP117338:c996508-995981 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT270611 WP_000855692.1 NZ_CP117338:c996795-996505 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References