294628

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4281851..4282665 Replicon chromosome
Accession NZ_OU015323
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00004549 isolate AUSMDU00004549

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag KKQ99_RS21535 Protein ID WP_000971655.1
Coordinates 4281851..4282378 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag KKQ99_RS21540 Protein ID WP_000855692.1
Coordinates 4282375..4282665 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ99_RS21515 (4277151) 4277151..4279718 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
KKQ99_RS21520 (4279877) 4279877..4280398 + 522 WP_000858988.1 hypothetical protein -
KKQ99_RS21525 (4280570) 4280570..4281226 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
KKQ99_RS21530 (4281573) 4281573..4281778 + 206 Protein_4225 IS5/IS1182 family transposase -
KKQ99_RS21535 (4281851) 4281851..4282378 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
KKQ99_RS21540 (4282375) 4282375..4282665 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
KKQ99_RS21545 (4282935) 4282935..4283113 - 179 Protein_4228 IS3 family transposase -
KKQ99_RS21550 (4283354) 4283354..4283680 + 327 WP_000393302.1 hypothetical protein -
KKQ99_RS21555 (4283953) 4283953..4284300 - 348 WP_001669174.1 DUF1493 family protein -
KKQ99_RS21560 (4284285) 4284285..4284734 - 450 WP_000381610.1 membrane protein -
KKQ99_RS21565 (4285165) 4285165..4285608 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KKQ99_RS21570 (4286065) 4286065..4286715 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB / invC/sctN / invI / invJ / spaO/sctQ / spaP / spaQ / spaR / spaS / sicA / sipB/sspB / sipC/sspC / sipC/sspC / sipD / sipA/sspA / sicP / sptP / prgH / prgI / prgJ / prgK / orgA/sctK / orgB/SctL / orgC / avrA / avrA 4281602..4323750 42148
flank IS/Tn - - 4281602..4281778 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T294628 WP_000971655.1 NZ_OU015323:c4282378-4281851 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT294628 WP_000855692.1 NZ_OU015323:c4282665-4282375 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References