251995

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1682151..1682965 Replicon chromosome
Accession NZ_CP101375
Organism Salmonella enterica strain SC2016090

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NMU33_RS08240 Protein ID WP_000971655.1
Coordinates 1682151..1682678 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NMU33_RS08245 Protein ID WP_000855692.1
Coordinates 1682675..1682965 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU33_RS08220 (1677451) 1677451..1680018 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NMU33_RS08225 (1680177) 1680177..1680698 + 522 WP_000858988.1 hypothetical protein -
NMU33_RS08230 (1680870) 1680870..1681526 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NMU33_RS08235 (1681873) 1681873..1682078 + 206 Protein_1609 IS5/IS1182 family transposase -
NMU33_RS08240 (1682151) 1682151..1682678 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NMU33_RS08245 (1682675) 1682675..1682965 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NMU33_RS08250 (1683235) 1683235..1683413 - 179 Protein_1612 IS3 family transposase -
NMU33_RS08255 (1683654) 1683654..1683980 + 327 WP_000393302.1 hypothetical protein -
NMU33_RS08260 (1684253) 1684253..1684600 - 348 WP_001669174.1 DUF1493 family protein -
NMU33_RS08265 (1684585) 1684585..1685034 - 450 WP_000381610.1 membrane protein -
NMU33_RS08270 (1685465) 1685465..1685908 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NMU33_RS08275 (1686365) 1686365..1687015 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1681902..1692328 10426
flank IS/Tn - - 1681902..1682078 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251995 WP_000971655.1 NZ_CP101375:c1682678-1682151 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT251995 WP_000855692.1 NZ_CP101375:c1682965-1682675 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References