221462

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 522760..523574 Replicon chromosome
Accession NZ_CP085798
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latias

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF55_RS02520 Protein ID WP_000971655.1
Coordinates 522760..523287 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF55_RS02525 Protein ID WP_000855694.1
Coordinates 523284..523574 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF55_RS02495 (519049) 519049..519447 + 399 Protein_481 cytoplasmic protein -
LJF55_RS02500 (520033) 520033..520701 + 669 WP_000445914.1 hypothetical protein -
LJF55_RS02505 (520728) 520728..521222 + 495 WP_000424949.1 hypothetical protein -
LJF55_RS02510 (521467) 521467..522123 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF55_RS02515 (522482) 522482..522687 + 206 Protein_485 IS5/IS1182 family transposase -
LJF55_RS02520 (522760) 522760..523287 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF55_RS02525 (523284) 523284..523574 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF55_RS02530 (523844) 523844..524033 - 190 Protein_488 IS3 family transposase -
LJF55_RS02535 (524437) 524437..524880 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF55_RS02540 (525336) 525336..525986 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF55_RS02545 (525983) 525983..527671 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 522511..522687 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221462 WP_000971655.1 NZ_CP085798:c523287-522760 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221462 NZ_CP117396:2369677-2369961 [Salmonella enterica subsp. enterica serovar Uganda]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAGCTGGGACATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGCGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221462 WP_000855694.1 NZ_CP085798:c523574-523284 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221462 NZ_CP117396:2369439-2369687 [Salmonella enterica subsp. enterica serovar Uganda]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACTGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References