257739

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 988525..989339 Replicon chromosome
Accession NZ_CP104358
Organism Salmonella enterica strain PNUSAS119065

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag N4275_RS04720 Protein ID WP_000971655.1
Coordinates 988525..989052 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag N4275_RS04725 Protein ID WP_000855694.1
Coordinates 989049..989339 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4275_RS04695 (984814) 984814..985212 + 399 Protein_919 cytoplasmic protein -
N4275_RS04700 (985798) 985798..986466 + 669 WP_000445914.1 hypothetical protein -
N4275_RS04705 (986493) 986493..986987 + 495 WP_000424949.1 hypothetical protein -
N4275_RS04710 (987232) 987232..987888 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
N4275_RS04715 (988247) 988247..988452 + 206 Protein_923 IS5/IS1182 family transposase -
N4275_RS04720 (988525) 988525..989052 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
N4275_RS04725 (989049) 989049..989339 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
N4275_RS04730 (989609) 989609..989798 - 190 Protein_926 IS3 family transposase -
N4275_RS04735 (990202) 990202..990645 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
N4275_RS04740 (991101) 991101..991751 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
N4275_RS04745 (991748) 991748..993436 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 988276..988452 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T257739 WP_000971655.1 NZ_CP104358:c989052-988525 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT257739 WP_000855694.1 NZ_CP104358:c989339-989049 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References