Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3913655..3914469 Replicon chromosome
Accession NZ_CP047522
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11216

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag DXN15_RS19145 Protein ID WP_000971655.1
Coordinates 3913942..3914469 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag DXN15_RS19140 Protein ID WP_000855692.1
Coordinates 3913655..3913945 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN15_RS19110 (3909605) 3909605..3910255 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
DXN15_RS19115 (3910712) 3910712..3911155 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
DXN15_RS19120 (3911586) 3911586..3912035 + 450 WP_000381610.1 membrane protein -
DXN15_RS19125 (3912020) 3912020..3912367 + 348 WP_001669174.1 DUF1493 family protein -
DXN15_RS19130 (3912640) 3912640..3912966 - 327 WP_000393302.1 hypothetical protein -
DXN15_RS19135 (3913207) 3913207..3913385 + 179 Protein_3723 IS3 family transposase -
DXN15_RS19140 (3913655) 3913655..3913945 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
DXN15_RS19145 (3913942) 3913942..3914469 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
DXN15_RS19150 (3914542) 3914542..3914747 - 206 Protein_3726 IS5/IS1182 family transposase -
DXN15_RS19155 (3915094) 3915094..3915750 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
DXN15_RS19160 (3915922) 3915922..3916443 - 522 WP_000858988.1 hypothetical protein -
DXN15_RS19165 (3916602) 3916602..3919169 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3914542..3914718 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T146345 WP_000971655.1 NZ_CP047522:3913942-3914469 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T146345 NZ_CP062742:c2851633-2851457 [Escherichia coli O157:H7]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT146345 WP_000855692.1 NZ_CP047522:3913655-3913945 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT146345 NZ_CP062742:c2851411-2850995 [Escherichia coli O157:H7]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCAGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References