270172

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 990330..991144 Replicon chromosome
Accession NZ_CP117244
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag PQQ30_RS04745 Protein ID WP_000971655.1
Coordinates 990330..990857 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag PQQ30_RS04750 Protein ID WP_000855692.1
Coordinates 990854..991144 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ30_RS04725 (985630) 985630..988197 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
PQQ30_RS04730 (988356) 988356..988877 + 522 WP_000858988.1 hypothetical protein -
PQQ30_RS04735 (989049) 989049..989705 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQQ30_RS04740 (990052) 990052..990257 + 206 Protein_929 IS5/IS1182 family transposase -
PQQ30_RS04745 (990330) 990330..990857 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
PQQ30_RS04750 (990854) 990854..991144 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
PQQ30_RS04755 (991414) 991414..991592 - 179 Protein_932 IS3 family transposase -
PQQ30_RS04760 (991833) 991833..992159 + 327 WP_000393302.1 hypothetical protein -
PQQ30_RS04765 (992432) 992432..992779 - 348 WP_001669174.1 DUF1493 family protein -
PQQ30_RS04770 (992764) 992764..993213 - 450 WP_000381610.1 membrane protein -
PQQ30_RS04775 (993644) 993644..994087 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQQ30_RS04780 (994544) 994544..995194 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 990081..1000507 10426
flank IS/Tn - - 990081..990257 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T270172 WP_000971655.1 NZ_CP117244:c990857-990330 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT270172 WP_000855692.1 NZ_CP117244:c991144-990854 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References