202569

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 995773..996587 Replicon chromosome
Accession NZ_CP074663
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag BG493_RS04755 Protein ID WP_000971655.1
Coordinates 995773..996300 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag BG493_RS04760 Protein ID WP_000855692.1
Coordinates 996297..996587 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG493_RS04735 (991073) 991073..993640 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
BG493_RS04740 (993799) 993799..994320 + 522 WP_000858988.1 hypothetical protein -
BG493_RS04745 (994492) 994492..995148 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
BG493_RS04750 (995495) 995495..995700 + 206 Protein_932 IS5/IS1182 family transposase -
BG493_RS04755 (995773) 995773..996300 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
BG493_RS04760 (996297) 996297..996587 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
BG493_RS04765 (996857) 996857..997035 - 179 Protein_935 IS3 family transposase -
BG493_RS04770 (997276) 997276..997602 + 327 WP_000393302.1 hypothetical protein -
BG493_RS04775 (997875) 997875..998222 - 348 WP_001669174.1 DUF1493 family protein -
BG493_RS04780 (998207) 998207..998656 - 450 WP_000381610.1 membrane protein -
BG493_RS04785 (999087) 999087..999530 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
BG493_RS04790 (999987) 999987..1000637 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 994492..1005950 11458
flank IS/Tn - - 995524..995700 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T202569 WP_000971655.1 NZ_CP074663:c996300-995773 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T202569 NZ_CP099506:c1812465-1812361 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT202569 WP_000855692.1 NZ_CP074663:c996587-996297 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT202569 NZ_CP099506:1812267-1812305 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References