282657

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 995605..996419 Replicon chromosome
Accession NZ_CP126138
Organism Salmonella enterica subsp. enterica serovar Kottbus strain DSK01

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag QNM33_RS04770 Protein ID WP_000971655.1
Coordinates 995605..996132 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag QNM33_RS04775 Protein ID WP_000855692.1
Coordinates 996129..996419 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNM33_RS04750 (990905) 990905..993472 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
QNM33_RS04755 (993631) 993631..994152 + 522 WP_000858988.1 hypothetical protein -
QNM33_RS04760 (994324) 994324..994980 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
QNM33_RS04765 (995327) 995327..995532 + 206 Protein_934 IS5/IS1182 family transposase -
QNM33_RS04770 (995605) 995605..996132 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
QNM33_RS04775 (996129) 996129..996419 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
QNM33_RS04780 (996689) 996689..996867 - 179 Protein_937 IS3 family transposase -
QNM33_RS04785 (997108) 997108..997434 + 327 WP_000393302.1 hypothetical protein -
QNM33_RS04790 (997707) 997707..998054 - 348 WP_001669174.1 DUF1493 family protein -
QNM33_RS04795 (998039) 998039..998488 - 450 WP_000381610.1 membrane protein -
QNM33_RS04800 (998919) 998919..999362 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
QNM33_RS04805 (999819) 999819..1000469 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 995356..1005782 10426
flank IS/Tn - - 995356..995532 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T282657 WP_000971655.1 NZ_CP126138:c996132-995605 [Salmonella enterica subsp. enterica serovar Kottbus]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT282657 WP_000855692.1 NZ_CP126138:c996419-996129 [Salmonella enterica subsp. enterica serovar Kottbus]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References