Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028033..1028847 Replicon chromosome
Accession NZ_CP117370
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain RM054

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag PQP97_RS04960 Protein ID WP_000971655.1
Coordinates 1028033..1028560 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag PQP97_RS04965 Protein ID WP_000855692.1
Coordinates 1028557..1028847 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP97_RS04940 (1023333) 1023333..1025900 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
PQP97_RS04945 (1026059) 1026059..1026580 + 522 WP_000858988.1 hypothetical protein -
PQP97_RS04950 (1026752) 1026752..1027408 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQP97_RS04955 (1027755) 1027755..1027960 + 206 Protein_972 IS5/IS1182 family transposase -
PQP97_RS04960 (1028033) 1028033..1028560 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
PQP97_RS04965 (1028557) 1028557..1028847 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
PQP97_RS04970 (1029117) 1029117..1029295 - 179 Protein_975 IS3 family transposase -
PQP97_RS04975 (1029536) 1029536..1029862 + 327 WP_000393302.1 hypothetical protein -
PQP97_RS04980 (1030135) 1030135..1030482 - 348 WP_001669174.1 DUF1493 family protein -
PQP97_RS04985 (1030467) 1030467..1030916 - 450 WP_000381610.1 membrane protein -
PQP97_RS04990 (1031347) 1031347..1031790 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQP97_RS04995 (1032247) 1032247..1032897 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1027784..1027960 176
inside Genomic island - invH / invF / invG / invE / invA / invB 1027784..1038210 10426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T270872 WP_000971655.1 NZ_CP117370:c1028560-1028033 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT270872 WP_000855692.1 NZ_CP117370:c1028847-1028557 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References