Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 988505..989319 Replicon chromosome
Accession NZ_CP122301
Organism Salmonella enterica strain 27A

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag P8R57_RS04715 Protein ID WP_000971655.1
Coordinates 988505..989032 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P8R57_RS04720 Protein ID WP_000855694.1
Coordinates 989029..989319 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R57_RS04690 (984794) 984794..985192 + 399 Protein_918 cytoplasmic protein -
P8R57_RS04695 (985778) 985778..986446 + 669 WP_000445914.1 hypothetical protein -
P8R57_RS04700 (986473) 986473..986967 + 495 WP_000424949.1 hypothetical protein -
P8R57_RS04705 (987212) 987212..987868 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
P8R57_RS04710 (988227) 988227..988432 + 206 Protein_922 IS5/IS1182 family transposase -
P8R57_RS04715 (988505) 988505..989032 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
P8R57_RS04720 (989029) 989029..989319 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P8R57_RS04725 (989589) 989589..989778 - 190 Protein_925 IS3 family transposase -
P8R57_RS04730 (990182) 990182..990625 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P8R57_RS04735 (991081) 991081..991731 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
P8R57_RS04740 (991728) 991728..993416 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 988256..988432 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T276607 WP_000971655.1 NZ_CP122301:c989032-988505 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT276607 WP_000855694.1 NZ_CP122301:c989319-989029 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References