Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1026868..1027682 Replicon chromosome
Accession NZ_CP088138
Organism Salmonella enterica subsp. enterica serovar Hissar strain SCPM-O-B-4549

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LRM92_RS04965 Protein ID WP_000971655.1
Coordinates 1026868..1027395 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag LRM92_RS04970 Protein ID WP_000855692.1
Coordinates 1027392..1027682 (-) Length 97 a.a.

Genomic Context

LRM92_RS04950LRM92_RS04960LRM92_RS04980LRM92_RS05000LRM92_RS04945LRM92_RS04955LRM92_RS04965LRM92_RS04970LRM92_RS04975LRM92_RS04985LRM92_RS04990LRM92_RS04995
Location: 1024894..1025415 (522 bp)
Type: Others
Protein ID: WP_000858988.1
Location: 1026590..1026795 (206 bp)
Type: Others
Protein ID: Protein_977
Location: 1028371..1028697 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 1031082..1031732 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 1022168..1024735 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 1025587..1026243 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 1026868..1027395 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 1027392..1027682 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 1027952..1028130 (179 bp)
Type: Others
Protein ID: Protein_980
Location: 1028970..1029317 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 1029302..1029751 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 1030182..1030625 (444 bp)
Type: Others
Protein ID: WP_000715092.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LRM92_RS04945 (1022168)1022168..1024735-2568WP_001005807.1DNA mismatch repair protein MutS-
LRM92_RS04950 (1024894)1024894..1025415+522WP_000858988.1hypothetical protein-
LRM92_RS04955 (1025587)1025587..1026243-657WP_000420452.1protein-serine/threonine phosphatase-
LRM92_RS04960 (1026590)1026590..1026795+206Protein_977IS5/IS1182 family transposase-
LRM92_RS04965 (1026868)1026868..1027395-528WP_000971655.1GNAT family N-acetyltransferaseToxin
LRM92_RS04970 (1027392)1027392..1027682-291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
LRM92_RS04975 (1027952)1027952..1028130-179Protein_980IS3 family transposase-
LRM92_RS04980 (1028371)1028371..1028697+327WP_000393302.1hypothetical protein-
LRM92_RS04985 (1028970)1028970..1029317-348WP_001669174.1DUF1493 family protein-
LRM92_RS04990 (1029302)1029302..1029751-450WP_000381610.1membrane protein-
LRM92_RS04995 (1030182)1030182..1030625-444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
LRM92_RS05000 (1031082)1031082..1031732+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB1026619..103704510426
flankIS/Tn--1026619..1026795176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T226793 WP_000971655.1 NZ_CP088138:c1027395-1026868 [Salmonella enterica subsp. enterica serovar Hissar]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T226793 NZ_CP122629:882051-882458 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT226793 WP_000855692.1 NZ_CP088138:c1027682-1027392 [Salmonella enterica subsp. enterica serovar Hissar]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT226793 NZ_CP122629:881804-882070 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References