226793

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1026868..1027682 Replicon chromosome
Accession NZ_CP088138
Organism Salmonella enterica subsp. enterica serovar Hissar strain SCPM-O-B-4549

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LRM92_RS04965 Protein ID WP_000971655.1
Coordinates 1026868..1027395 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag LRM92_RS04970 Protein ID WP_000855692.1
Coordinates 1027392..1027682 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM92_RS04945 (1022168) 1022168..1024735 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
LRM92_RS04950 (1024894) 1024894..1025415 + 522 WP_000858988.1 hypothetical protein -
LRM92_RS04955 (1025587) 1025587..1026243 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LRM92_RS04960 (1026590) 1026590..1026795 + 206 Protein_977 IS5/IS1182 family transposase -
LRM92_RS04965 (1026868) 1026868..1027395 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LRM92_RS04970 (1027392) 1027392..1027682 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
LRM92_RS04975 (1027952) 1027952..1028130 - 179 Protein_980 IS3 family transposase -
LRM92_RS04980 (1028371) 1028371..1028697 + 327 WP_000393302.1 hypothetical protein -
LRM92_RS04985 (1028970) 1028970..1029317 - 348 WP_001669174.1 DUF1493 family protein -
LRM92_RS04990 (1029302) 1029302..1029751 - 450 WP_000381610.1 membrane protein -
LRM92_RS04995 (1030182) 1030182..1030625 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LRM92_RS05000 (1031082) 1031082..1031732 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1026619..1037045 10426
flank IS/Tn - - 1026619..1026795 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T226793 WP_000971655.1 NZ_CP088138:c1027395-1026868 [Salmonella enterica subsp. enterica serovar Hissar]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T226793 NZ_CP122629:882051-882458 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT226793 WP_000855692.1 NZ_CP088138:c1027682-1027392 [Salmonella enterica subsp. enterica serovar Hissar]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT226793 NZ_CP122629:881804-882070 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References