Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1261000..1261814 Replicon chromosome
Accession NZ_CP098741
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain HJL222

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NCG87_RS06210 Protein ID WP_000971655.1
Coordinates 1261287..1261814 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NCG87_RS06205 Protein ID WP_000855692.1
Coordinates 1261000..1261290 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCG87_RS06175 (1256950) 1256950..1257600 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
NCG87_RS06180 (1258057) 1258057..1258500 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NCG87_RS06185 (1258931) 1258931..1259380 + 450 WP_000381610.1 membrane protein -
NCG87_RS06190 (1259365) 1259365..1259712 + 348 WP_001669174.1 DUF1493 family protein -
NCG87_RS06195 (1259985) 1259985..1260311 - 327 WP_000393302.1 hypothetical protein -
NCG87_RS06200 (1260552) 1260552..1260730 + 179 Protein_1205 IS3 family transposase -
NCG87_RS06205 (1261000) 1261000..1261290 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NCG87_RS06210 (1261287) 1261287..1261814 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NCG87_RS06215 (1261887) 1261887..1262092 - 206 Protein_1208 IS5/IS1182 family transposase -
NCG87_RS06220 (1262439) 1262439..1263095 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
NCG87_RS06225 (1263267) 1263267..1263788 - 522 WP_000858988.1 hypothetical protein -
NCG87_RS06230 (1263947) 1263947..1266514 + 2568 WP_088365275.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1261887..1262063 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T247949 WP_000971655.1 NZ_CP098741:1261287-1261814 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT247949 WP_000855692.1 NZ_CP098741:1261000-1261290 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References