Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1076754..1077568 Replicon chromosome
Accession NZ_CP101373
Organism Salmonella enterica strain SC2016042

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NMU32_RS05185 Protein ID WP_000971655.1
Coordinates 1076754..1077281 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NMU32_RS05190 Protein ID WP_000855692.1
Coordinates 1077278..1077568 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU32_RS05165 (1072054) 1072054..1074621 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NMU32_RS05170 (1074780) 1074780..1075301 + 522 WP_000858988.1 hypothetical protein -
NMU32_RS05175 (1075473) 1075473..1076129 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NMU32_RS05180 (1076476) 1076476..1076681 + 206 Protein_1017 IS5/IS1182 family transposase -
NMU32_RS05185 (1076754) 1076754..1077281 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NMU32_RS05190 (1077278) 1077278..1077568 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NMU32_RS05195 (1077838) 1077838..1078016 - 179 Protein_1020 IS3 family transposase -
NMU32_RS05200 (1078257) 1078257..1078583 + 327 WP_000393302.1 hypothetical protein -
NMU32_RS05205 (1078856) 1078856..1079203 - 348 WP_001669174.1 DUF1493 family protein -
NMU32_RS05210 (1079188) 1079188..1079637 - 450 WP_000381610.1 membrane protein -
NMU32_RS05215 (1080068) 1080068..1080511 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NMU32_RS05220 (1080968) 1080968..1081618 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1076505..1086931 10426
flank IS/Tn - - 1076505..1076681 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251971 WP_000971655.1 NZ_CP101373:c1077281-1076754 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT251971 WP_000855692.1 NZ_CP101373:c1077568-1077278 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References