202542

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 988206..989020 Replicon chromosome
Accession NZ_CP074661
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN008104

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag A9D71_RS04720 Protein ID WP_000971655.1
Coordinates 988206..988733 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag A9D71_RS04725 Protein ID WP_000855694.1
Coordinates 988730..989020 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9D71_RS04695 (984495) 984495..984893 + 399 Protein_919 cytoplasmic protein -
A9D71_RS04700 (985479) 985479..986147 + 669 WP_000445914.1 hypothetical protein -
A9D71_RS04705 (986174) 986174..986668 + 495 WP_000424949.1 hypothetical protein -
A9D71_RS04710 (986913) 986913..987569 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
A9D71_RS04715 (987928) 987928..988133 + 206 Protein_923 IS5/IS1182 family transposase -
A9D71_RS04720 (988206) 988206..988733 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
A9D71_RS04725 (988730) 988730..989020 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
A9D71_RS04730 (989290) 989290..989479 - 190 Protein_926 IS3 family transposase -
A9D71_RS04735 (989883) 989883..990326 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
A9D71_RS04740 (990782) 990782..991432 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
A9D71_RS04745 (991429) 991429..993117 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 987957..988133 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T202542 WP_000971655.1 NZ_CP074661:c988733-988206 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T202542 NZ_CP099497:2798515-2798766 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATACAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT202542 WP_000855694.1 NZ_CP074661:c989020-988730 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT202542 NZ_CP099497:2798756-2798929 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References