Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4280885..4281699 Replicon chromosome
Accession NZ_OU015340
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00027944 isolate AUSMDU00027944

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag KKR00_RS21520 Protein ID WP_000971655.1
Coordinates 4280885..4281412 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag KKR00_RS21525 Protein ID WP_000855692.1
Coordinates 4281409..4281699 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKR00_RS21500 (4276185) 4276185..4278752 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
KKR00_RS21505 (4278911) 4278911..4279432 + 522 WP_000858988.1 hypothetical protein -
KKR00_RS21510 (4279604) 4279604..4280260 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
KKR00_RS21515 (4280607) 4280607..4280812 + 206 Protein_4219 IS5/IS1182 family transposase -
KKR00_RS21520 (4280885) 4280885..4281412 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
KKR00_RS21525 (4281409) 4281409..4281699 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
KKR00_RS21530 (4281969) 4281969..4282147 - 179 Protein_4222 IS3 family transposase -
KKR00_RS21535 (4282388) 4282388..4282714 + 327 WP_000393302.1 hypothetical protein -
KKR00_RS21540 (4282987) 4282987..4283334 - 348 WP_001669174.1 DUF1493 family protein -
KKR00_RS21545 (4283319) 4283319..4283768 - 450 WP_000381610.1 membrane protein -
KKR00_RS21550 (4284199) 4284199..4284642 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KKR00_RS21555 (4285099) 4285099..4285749 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 4280636..4291062 10426
flank IS/Tn - - 4280636..4280812 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T294649 WP_000971655.1 NZ_OU015340:c4281412-4280885 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT294649 WP_000855692.1 NZ_OU015340:c4281699-4281409 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References