265921

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1029353..1030167 Replicon chromosome
Accession NZ_CP113536
Organism Salmonella enterica strain ZCX

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3Z5UEC2
Locus tag OXV07_RS04980 Protein ID WP_023198251.1
Coordinates 1029353..1029880 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag OXV07_RS04985 Protein ID WP_000855692.1
Coordinates 1029877..1030167 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV07_RS04960 (1024653) 1024653..1027220 - 2568 WP_023139136.1 DNA mismatch repair protein MutS -
OXV07_RS04965 (1027379) 1027379..1027900 + 522 WP_000858988.1 hypothetical protein -
OXV07_RS04970 (1028072) 1028072..1028728 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
OXV07_RS04975 (1029075) 1029075..1029280 + 206 Protein_976 IS5/IS1182 family transposase -
OXV07_RS04980 (1029353) 1029353..1029880 - 528 WP_023198251.1 GNAT family N-acetyltransferase Toxin
OXV07_RS04985 (1029877) 1029877..1030167 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
OXV07_RS04990 (1030437) 1030437..1030615 - 179 Protein_979 IS3 family transposase -
OXV07_RS04995 (1030856) 1030856..1031182 + 327 WP_000393302.1 hypothetical protein -
OXV07_RS05000 (1031455) 1031455..1031802 - 348 WP_001669174.1 DUF1493 family protein -
OXV07_RS05005 (1031787) 1031787..1032236 - 450 WP_000381610.1 membrane protein -
OXV07_RS05010 (1032667) 1032667..1033110 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
OXV07_RS05015 (1033567) 1033567..1034217 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1029104..1039530 10426
flank IS/Tn - - 1029104..1029280 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19127.94 Da        Isoelectric Point: 9.3903

>T265921 WP_023198251.1 NZ_CP113536:c1029880-1029353 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPDAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT265921 WP_000855692.1 NZ_CP113536:c1030167-1029877 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z5UEC2

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References