221610

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3671672..3672486 Replicon chromosome
Accession NZ_CP085803
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Glaceon

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF50_RS18015 Protein ID WP_000971655.1
Coordinates 3671959..3672486 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF50_RS18010 Protein ID WP_000855694.1
Coordinates 3671672..3671962 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF50_RS17990 (3667575) 3667575..3669263 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
LJF50_RS17995 (3669260) 3669260..3669910 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF50_RS18000 (3670366) 3670366..3670809 + 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF50_RS18005 (3671213) 3671213..3671402 + 190 Protein_3500 IS3 family transposase -
LJF50_RS18010 (3671672) 3671672..3671962 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF50_RS18015 (3671959) 3671959..3672486 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF50_RS18020 (3672559) 3672559..3672764 - 206 Protein_3503 IS5/IS1182 family transposase -
LJF50_RS18025 (3673123) 3673123..3673779 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF50_RS18030 (3674024) 3674024..3674518 - 495 WP_000424949.1 hypothetical protein -
LJF50_RS18035 (3674545) 3674545..3675213 - 669 WP_000445914.1 hypothetical protein -
LJF50_RS18040 (3675799) 3675799..3676197 - 399 Protein_3507 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3672559..3672735 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221610 WP_000971655.1 NZ_CP085803:3671959-3672486 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221610 NZ_CP117554:1839191-1839562 [Erwinia amylovora]
ATGATTTATTTTCTATCCAGTCAAGACATCATCGGCATTCATCAGCGTATGATCGTCGCTTACGGCGGTCTTGCCGGTTA
TGCCGATCCTGGTCGGATAGAAAGTATGGCAACACGGATTCTGAACCGCCACATCTACGAAGGTGAGGATGATATCTATA
TTCTGGCAGCTGCATATCTGCTGGCCATTGCGCGCGGGCATTGTTTCAATGATGCAAATAAGAGAACCGCATTTGCTTCA
ACTGCTTTATTCCTGCGCCGTAATGGCATTCTTCTTCGCTTTTCCCCAATCCATGAACAGCTGACTGTCTCAGCAGCACA
GGGGAGCCTGGATGTGTGGCACATTGCTGAAGCACTGAAACAGTCGACATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221610 WP_000855694.1 NZ_CP085803:3671672-3671962 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221610 NZ_CP117554:1838973-1839194 [Erwinia amylovora]
ATGCAAGCTATAAACTTTACTACCGCCCGTAACGAACTGGCATCAGTTCTTGATAGCGTTGCCAGCGGTGAGCCAGTTAT
GATCACCCGCAGATCGGCCAAATCCGTGGTTGTGGTTGATGCCGCGCAGTATGAAAAAATGCAAAAAATTCAGGCAGAAT
CGGACTTTGATTGGTTGTTTACAGAACATGGCCAGACGCTTGAAGCTCTTAAAAACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References