202975

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1006724..1007538 Replicon chromosome
Accession NZ_CP075116
Organism Salmonella enterica subsp. enterica serovar Stanleyville strain CFSAN059881

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag CCO40_RS04810 Protein ID WP_000971655.1
Coordinates 1006724..1007251 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag CCO40_RS04815 Protein ID WP_000855692.1
Coordinates 1007248..1007538 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO40_RS04790 (1002024) 1002024..1004591 - 2568 WP_001005802.1 DNA mismatch repair protein MutS -
CCO40_RS04795 (1004750) 1004750..1005271 + 522 WP_094889101.1 cytoplasmic protein -
CCO40_RS04800 (1005443) 1005443..1006099 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
CCO40_RS04805 (1006446) 1006446..1006651 + 206 Protein_943 IS5/IS1182 family transposase -
CCO40_RS04810 (1006724) 1006724..1007251 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
CCO40_RS04815 (1007248) 1007248..1007538 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
CCO40_RS04820 (1007808) 1007808..1007986 - 179 Protein_946 IS3 family transposase -
CCO40_RS04825 (1008227) 1008227..1008553 + 327 WP_000393302.1 hypothetical protein -
CCO40_RS04830 (1008826) 1008826..1009173 - 348 WP_001669174.1 DUF1493 family protein -
CCO40_RS04835 (1009158) 1009158..1009607 - 450 WP_000381617.1 hypothetical protein -
CCO40_RS04840 (1010039) 1010039..1010482 - 444 WP_094889102.1 SPI-1 type III secretion system invasion lipoprotein InvH -
CCO40_RS04845 (1010939) 1010939..1011589 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1006475..1016902 10427
flank IS/Tn - - 1006475..1006651 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T202975 WP_000971655.1 NZ_CP075116:c1007251-1006724 [Salmonella enterica subsp. enterica serovar Stanleyville]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T202975 NZ_CP099805:456005-456295 [Yersinia ruckeri]
ATGACCTTTAATATCGACTTTGACGAACGGGCATTAAAAGAATGGCACAAACTAGATAAAACTATCCGAGAGCAATTTAA
AAAGAAACTAAGAAAATTACAGGAAAATCCCTATATTGAGTCAGCACGTTTGCACGGTGATCTGGCTGGTTGTTTCAAAA
TAAAATTACGCGCATCTGGCTTTCGGTTGATTTACCAAGTTATCGATGAGGAGATTGTGATTTTGATCGTTGCTGTTGGT
AAACGGGAAGATGAAAAAGCTTATGATCTTGCCAAGAAGCGAATCCAATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT202975 WP_000855692.1 NZ_CP075116:c1007538-1007248 [Salmonella enterica subsp. enterica serovar Stanleyville]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT202975 NZ_CP099805:455761-456015 [Yersinia ruckeri]
ATGAGTACTATCCAAATTCGTGTGGATGATGAACTGAAGAAAAGTGCATATCAGGCGTTTGAAAAACTGAATCTTTCGCC
TTCTGATGCACTACGCCTGTTCCTACGTTATGTTGCAGAGAACGAAAAGCTGCCTTTTTCAGAAGTATCCGTCATGGTCA
GTAATCAAGATGAGGATGCTGATATTTTGGCTGTTGTCCGTGAACGTTTGAAAAATCCTGCAAAGCGTATCAGAGTAAAT
ATTGATGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References