Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028168..1028982 Replicon chromosome
Accession NZ_CP098834
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain GD19PS1

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NFH28_RS04945 Protein ID WP_000971655.1
Coordinates 1028168..1028695 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NFH28_RS04950 Protein ID WP_000855692.1
Coordinates 1028692..1028982 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH28_RS04925 (1023468) 1023468..1026035 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NFH28_RS04930 (1026194) 1026194..1026715 + 522 WP_000858988.1 hypothetical protein -
NFH28_RS04935 (1026887) 1026887..1027543 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NFH28_RS04940 (1027890) 1027890..1028095 + 206 Protein_972 IS5/IS1182 family transposase -
NFH28_RS04945 (1028168) 1028168..1028695 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NFH28_RS04950 (1028692) 1028692..1028982 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NFH28_RS04955 (1029252) 1029252..1029430 - 179 Protein_975 IS3 family transposase -
NFH28_RS04960 (1029671) 1029671..1029997 + 327 WP_000393302.1 hypothetical protein -
NFH28_RS04965 (1030270) 1030270..1030617 - 348 WP_001669174.1 DUF1493 family protein -
NFH28_RS04970 (1030602) 1030602..1031051 - 450 WP_000381610.1 membrane protein -
NFH28_RS04975 (1031482) 1031482..1031925 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NFH28_RS04980 (1032382) 1032382..1033032 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1027919..1038345 10426
flank IS/Tn - - 1027919..1028095 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T248151 WP_000971655.1 NZ_CP098834:c1028695-1028168 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT248151 WP_000855692.1 NZ_CP098834:c1028982-1028692 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References