Detailed information of TA system TA221877

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4502909..4503723
• Replicon: chromosome
• Accession: NZ_CP085815
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Slowbro

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: Q57KM2
• Locus tag: LJF37_RS21905
• Protein ID: WP_000971655.1
• Coordinates: 4502909..4503436 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: LJF37_RS21910
• Protein ID: WP_000855694.1
• Coordinates: 4503433..4503723 (-)
• Length: 97 a.a.

Genomic Context

Location: 4499198..4499596 (399 bp)
Type: Others
Protein ID: Protein_4258

Location: 4500182..4500850 (669 bp)
Type: Others
Protein ID: WP_000445914.1

Location: 4500877..4501371 (495 bp)
Type: Others
Protein ID: WP_000424949.1

Location: 4502631..4502836 (206 bp)
Type: Others
Protein ID: Protein_4262

Location: 4505485..4506135 (651 bp)
Type: Others
Protein ID: WP_001674874.1

Location: 4506132..4507820 (1689 bp)
Type: Others
Protein ID: WP_000848113.1

Location: 4501616..4502272 (657 bp)
Type: Others
Protein ID: WP_000420452.1

Location: 4502909..4503436 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1

Location: 4503433..4503723 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1

Location: 4503993..4504182 (190 bp)
Type: Others
Protein ID: Protein_4265

Location: 4504586..4505029 (444 bp)
Type: Others
Protein ID: WP_000715097.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF37_RS21880 (4499198)	4499198..4499596	+	399	Protein_4258	cytoplasmic protein	-
LJF37_RS21885 (4500182)	4500182..4500850	+	669	WP_000445914.1	hypothetical protein	-
LJF37_RS21890 (4500877)	4500877..4501371	+	495	WP_000424949.1	hypothetical protein	-
LJF37_RS21895 (4501616)	4501616..4502272	-	657	WP_000420452.1	protein-serine/threonine phosphatase	-
LJF37_RS21900 (4502631)	4502631..4502836	+	206	Protein_4262	IS5/IS1182 family transposase	-
LJF37_RS21905 (4502909)	4502909..4503436	-	528	WP_000971655.1	GNAT family N-acetyltransferase	Toxin
LJF37_RS21910 (4503433)	4503433..4503723	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
LJF37_RS21915 (4503993)	4503993..4504182	-	190	Protein_4265	IS3 family transposase	-
LJF37_RS21920 (4504586)	4504586..4505029	-	444	WP_000715097.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
LJF37_RS21925 (4505485)	4505485..4506135	+	651	WP_001674874.1	type III secretion system transcriptional activator InvF	-
LJF37_RS21930 (4506132)	4506132..4507820	+	1689	WP_000848113.1	type III secretion system outer membrane ring protein InvG	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 IS/Tn TA025955 3070795..3070971 0.007 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S IS/Tn TA026055 3068456..3068632 0.007 View UFRD01000002 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 IS/Tn TA010052 4599654..4599830 0.007	flank	IS/Tn	-	-	4502660..4502836	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19069.91 Da
• Isoelectric Point: 9.6420

>T221877 WP_000971655.1 NZ_CP085815:c4503436-4502909 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T221877 NZ_CP117615:314654-315181 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTGTATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGCTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT221877 WP_000855694.1 NZ_CP085815:c4503723-4503433 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT221877 NZ_CP117615:314381-314647 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

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Structures

Toxin

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• PDB: 6G96
• PDB: 7AK9

Antitoxin

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• AlphaFold DB: A0A3V8SJE7