Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4502909..4503723 Replicon chromosome
Accession NZ_CP085815
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowbro

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF37_RS21905 Protein ID WP_000971655.1
Coordinates 4502909..4503436 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF37_RS21910 Protein ID WP_000855694.1
Coordinates 4503433..4503723 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF37_RS21880 (4499198) 4499198..4499596 + 399 Protein_4258 cytoplasmic protein -
LJF37_RS21885 (4500182) 4500182..4500850 + 669 WP_000445914.1 hypothetical protein -
LJF37_RS21890 (4500877) 4500877..4501371 + 495 WP_000424949.1 hypothetical protein -
LJF37_RS21895 (4501616) 4501616..4502272 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF37_RS21900 (4502631) 4502631..4502836 + 206 Protein_4262 IS5/IS1182 family transposase -
LJF37_RS21905 (4502909) 4502909..4503436 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF37_RS21910 (4503433) 4503433..4503723 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF37_RS21915 (4503993) 4503993..4504182 - 190 Protein_4265 IS3 family transposase -
LJF37_RS21920 (4504586) 4504586..4505029 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF37_RS21925 (4505485) 4505485..4506135 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF37_RS21930 (4506132) 4506132..4507820 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4502660..4502836 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221877 WP_000971655.1 NZ_CP085815:c4503436-4502909 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221877 NZ_CP117615:314654-315181 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTGTATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGCTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221877 WP_000855694.1 NZ_CP085815:c4503723-4503433 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221877 NZ_CP117615:314381-314647 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References