258766

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1340577..1341391 Replicon chromosome
Accession NZ_CP104643
Organism Salmonella enterica strain 1020677

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag N5930_RS06400 Protein ID WP_000971655.1
Coordinates 1340577..1341104 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag N5930_RS06405 Protein ID WP_000855694.1
Coordinates 1341101..1341391 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5930_RS06375 (1336866) 1336866..1337264 + 399 Protein_1228 cytoplasmic protein -
N5930_RS06380 (1337850) 1337850..1338518 + 669 WP_000445914.1 hypothetical protein -
N5930_RS06385 (1338545) 1338545..1339039 + 495 WP_000424949.1 hypothetical protein -
N5930_RS06390 (1339284) 1339284..1339940 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
N5930_RS06395 (1340299) 1340299..1340504 + 206 Protein_1232 IS5/IS1182 family transposase -
N5930_RS06400 (1340577) 1340577..1341104 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
N5930_RS06405 (1341101) 1341101..1341391 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
N5930_RS06410 (1341661) 1341661..1341850 - 190 Protein_1235 IS3 family transposase -
N5930_RS06415 (1342254) 1342254..1342697 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
N5930_RS06420 (1343153) 1343153..1343803 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
N5930_RS06425 (1343800) 1343800..1345488 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1340328..1340504 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T258766 WP_000971655.1 NZ_CP104643:c1341104-1340577 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT258766 WP_000855694.1 NZ_CP104643:c1341391-1341101 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References