146630

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3960880..3961694 Replicon chromosome
Accession NZ_CP047548
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10169

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag DXN26_RS19480 Protein ID WP_000971655.1
Coordinates 3961167..3961694 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag DXN26_RS19475 Protein ID WP_000855692.1
Coordinates 3960880..3961170 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN26_RS19445 (3956830) 3956830..3957480 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
DXN26_RS19450 (3957937) 3957937..3958380 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
DXN26_RS19455 (3958811) 3958811..3959260 + 450 WP_000381610.1 membrane protein -
DXN26_RS19460 (3959245) 3959245..3959592 + 348 WP_001669174.1 DUF1493 family protein -
DXN26_RS19465 (3959865) 3959865..3960191 - 327 WP_000393302.1 hypothetical protein -
DXN26_RS19470 (3960432) 3960432..3960610 + 179 Protein_3790 IS3 family transposase -
DXN26_RS19475 (3960880) 3960880..3961170 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
DXN26_RS19480 (3961167) 3961167..3961694 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
DXN26_RS19485 (3961767) 3961767..3961972 - 206 Protein_3793 IS5/IS1182 family transposase -
DXN26_RS19490 (3962319) 3962319..3962975 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
DXN26_RS19495 (3963147) 3963147..3963668 - 522 WP_000858988.1 hypothetical protein -
DXN26_RS19500 (3963827) 3963827..3966394 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3961767..3961943 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T146630 WP_000971655.1 NZ_CP047548:3961167-3961694 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T146630 NZ_CP062769:283379-283486 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT146630 WP_000855692.1 NZ_CP047548:3960880-3961170 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT146630 NZ_CP062769:c283331-283265 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References