258043

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1034449..1035263 Replicon chromosome
Accession NZ_CP104479
Organism Salmonella enterica strain SalSpp_sample_09_No.5

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag N4G50_RS04955 Protein ID WP_000971655.1
Coordinates 1034449..1034976 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag N4G50_RS04960 Protein ID WP_000855694.1
Coordinates 1034973..1035263 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G50_RS04925 (1030737) 1030737..1031158 + 422 Protein_966 cytoplasmic protein -
N4G50_RS04930 (1031326) 1031326..1031565 + 240 Protein_967 hypothetical protein -
N4G50_RS04935 (1031722) 1031722..1032390 + 669 WP_024156635.1 hypothetical protein -
N4G50_RS04940 (1032417) 1032417..1032911 + 495 WP_000424942.1 hypothetical protein -
N4G50_RS04945 (1033156) 1033156..1033812 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
N4G50_RS04950 (1034171) 1034171..1034376 + 206 Protein_971 IS5/IS1182 family transposase -
N4G50_RS04955 (1034449) 1034449..1034976 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
N4G50_RS04960 (1034973) 1034973..1035263 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
N4G50_RS04965 (1035533) 1035533..1035733 - 201 Protein_974 IS3 family transposase -
N4G50_RS04970 (1035974) 1035974..1036300 + 327 WP_000393302.1 hypothetical protein -
N4G50_RS04975 (1036573) 1036573..1036920 - 348 WP_001555786.1 DUF1493 family protein -
N4G50_RS04980 (1036905) 1036905..1037354 - 450 WP_024156634.1 hypothetical protein -
N4G50_RS04985 (1037786) 1037786..1038229 - 444 WP_000715100.1 SPI-1 type III secretion system invasion lipoprotein InvH -
N4G50_RS04990 (1038685) 1038685..1039335 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1034200..1034376 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T258043 WP_000971655.1 NZ_CP104479:c1034976-1034449 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT258043 WP_000855694.1 NZ_CP104479:c1035263-1034973 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References