Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4195252..4196066 Replicon chromosome
Accession NZ_CP085814
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Plusle

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF38_RS20495 Protein ID WP_000971655.1
Coordinates 4195539..4196066 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF38_RS20490 Protein ID WP_000855694.1
Coordinates 4195252..4195542 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF38_RS20470 (4191155) 4191155..4192843 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
LJF38_RS20475 (4192840) 4192840..4193490 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF38_RS20480 (4193946) 4193946..4194389 + 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF38_RS20485 (4194793) 4194793..4194982 + 190 Protein_3990 IS3 family transposase -
LJF38_RS20490 (4195252) 4195252..4195542 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF38_RS20495 (4195539) 4195539..4196066 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF38_RS20500 (4196139) 4196139..4196344 - 206 Protein_3993 IS5/IS1182 family transposase -
LJF38_RS20505 (4196703) 4196703..4197359 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF38_RS20510 (4197604) 4197604..4198098 - 495 WP_000424949.1 hypothetical protein -
LJF38_RS20515 (4198125) 4198125..4198793 - 669 WP_000445914.1 hypothetical protein -
LJF38_RS20520 (4199379) 4199379..4199777 - 399 Protein_3997 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4196139..4196315 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221850 WP_000971655.1 NZ_CP085814:4195539-4196066 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221850 NZ_CP117606:c4387759-4387418 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCTGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCTA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCACCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTATGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221850 WP_000855694.1 NZ_CP085814:4195252-4195542 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221850 NZ_CP117606:4387754-4387831 [Escherichia albertii]
AGTCATAACTGCTATTCCTTGGAAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References