238592

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1022334..1023148 Replicon chromosome
Accession NZ_CP093445
Organism Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag MOV10_RS04865 Protein ID WP_000971655.1
Coordinates 1022334..1022861 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag MOV10_RS04870 Protein ID WP_000855694.1
Coordinates 1022858..1023148 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV10_RS04840 (1018536) 1018536..1018957 + 422 Protein_950 cytoplasmic protein -
MOV10_RS04845 (1019520) 1019520..1020188 + 669 WP_000445914.1 hypothetical protein -
MOV10_RS04850 (1020215) 1020215..1020709 + 495 WP_000424944.1 hypothetical protein -
MOV10_RS04855 (1020954) 1020954..1021610 - 657 WP_076741749.1 protein-serine/threonine phosphatase -
MOV10_RS04860 (1021837) 1021837..1022261 + 425 Protein_954 transposase -
MOV10_RS04865 (1022334) 1022334..1022861 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
MOV10_RS04870 (1022858) 1022858..1023148 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
MOV10_RS04875 (1023742) 1023742..1024068 + 327 WP_242105757.1 hypothetical protein -
MOV10_RS04880 (1024341) 1024341..1024688 - 348 WP_242105758.1 DUF1493 family protein -
MOV10_RS04885 (1024673) 1024673..1025122 - 450 WP_000381619.1 hypothetical protein -
MOV10_RS04890 (1025554) 1025554..1025997 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
MOV10_RS04895 (1026454) 1026454..1027104 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1022085..1032417 10332
flank IS/Tn - - 1022085..1022261 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T238592 WP_000971655.1 NZ_CP093445:c1022861-1022334 [Salmonella enterica subsp. enterica serovar Abeokuta]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T238592 NZ_LR890410:c213759-213481 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT238592 WP_000855694.1 NZ_CP093445:c1023148-1022858 [Salmonella enterica subsp. enterica serovar Abeokuta]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT238592 NZ_LR890410:c213481-213197 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References