269884

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1027707..1028521 Replicon chromosome
Accession NZ_CP117033
Organism Salmonella enterica strain PIW95_S14_0299

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag PQP07_RS04955 Protein ID WP_000971655.1
Coordinates 1027707..1028234 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag PQP07_RS04960 Protein ID WP_000855692.1
Coordinates 1028231..1028521 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP07_RS04935 (1023007) 1023007..1025574 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
PQP07_RS04940 (1025733) 1025733..1026254 + 522 WP_000858988.1 hypothetical protein -
PQP07_RS04945 (1026426) 1026426..1027082 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQP07_RS04950 (1027429) 1027429..1027634 + 206 Protein_971 IS5/IS1182 family transposase -
PQP07_RS04955 (1027707) 1027707..1028234 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
PQP07_RS04960 (1028231) 1028231..1028521 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
PQP07_RS04965 (1028791) 1028791..1028969 - 179 Protein_974 IS3 family transposase -
PQP07_RS04970 (1029210) 1029210..1029536 + 327 WP_000393302.1 hypothetical protein -
PQP07_RS04975 (1029809) 1029809..1030156 - 348 WP_001669174.1 DUF1493 family protein -
PQP07_RS04980 (1030141) 1030141..1030590 - 450 WP_000381610.1 membrane protein -
PQP07_RS04985 (1031021) 1031021..1031464 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQP07_RS04990 (1031921) 1031921..1032571 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1027458..1037884 10426
flank IS/Tn - - 1027458..1027634 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T269884 WP_000971655.1 NZ_CP117033:c1028234-1027707 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT269884 WP_000855692.1 NZ_CP117033:c1028521-1028231 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References