212650

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1027826..1028640 Replicon chromosome
Accession NZ_CP081187
Organism Salmonella enterica strain sg1722-1

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag K4F82_RS04940 Protein ID WP_000971655.1
Coordinates 1027826..1028353 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag K4F82_RS04945 Protein ID WP_000855692.1
Coordinates 1028350..1028640 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F82_RS04920 (1023126) 1023126..1025693 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
K4F82_RS04925 (1025852) 1025852..1026373 + 522 WP_000858988.1 hypothetical protein -
K4F82_RS04930 (1026545) 1026545..1027201 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
K4F82_RS04935 (1027548) 1027548..1027753 + 206 Protein_969 IS5/IS1182 family transposase -
K4F82_RS04940 (1027826) 1027826..1028353 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
K4F82_RS04945 (1028350) 1028350..1028640 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
K4F82_RS04950 (1028910) 1028910..1029088 - 179 Protein_972 IS3 family transposase -
K4F82_RS04955 (1029329) 1029329..1029655 + 327 WP_000393302.1 hypothetical protein -
K4F82_RS04960 (1029928) 1029928..1030275 - 348 WP_001669174.1 DUF1493 family protein -
K4F82_RS04965 (1030260) 1030260..1030709 - 450 WP_000381610.1 membrane protein -
K4F82_RS04970 (1031140) 1031140..1031583 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
K4F82_RS04975 (1032040) 1032040..1032690 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1027577..1038003 10426
flank IS/Tn - - 1027577..1027753 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T212650 WP_000971655.1 NZ_CP081187:c1028353-1027826 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T212650 NZ_CP107308:c4886634-4886350 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT212650 WP_000855692.1 NZ_CP081187:c1028640-1028350 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT212650 NZ_CP107308:c4886866-4886624 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References