263415

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1027891..1028705 Replicon chromosome
Accession NZ_CP110201
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 1104-65

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag OCK73_RS04950 Protein ID WP_000971655.1
Coordinates 1027891..1028418 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag OCK73_RS04955 Protein ID WP_000855692.1
Coordinates 1028415..1028705 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCK73_RS04930 (1023191) 1023191..1025758 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
OCK73_RS04935 (1025917) 1025917..1026438 + 522 WP_000858988.1 hypothetical protein -
OCK73_RS04940 (1026610) 1026610..1027266 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
OCK73_RS04945 (1027613) 1027613..1027818 + 206 Protein_970 IS5/IS1182 family transposase -
OCK73_RS04950 (1027891) 1027891..1028418 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
OCK73_RS04955 (1028415) 1028415..1028705 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
OCK73_RS04960 (1028975) 1028975..1029153 - 179 Protein_973 IS3 family transposase -
OCK73_RS04965 (1029394) 1029394..1029720 + 327 WP_000393302.1 hypothetical protein -
OCK73_RS04970 (1029993) 1029993..1030340 - 348 WP_001669174.1 DUF1493 family protein -
OCK73_RS04975 (1030325) 1030325..1030774 - 450 WP_000381610.1 membrane protein -
OCK73_RS04980 (1031205) 1031205..1031648 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
OCK73_RS04985 (1032105) 1032105..1032755 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1027642..1038068 10426
flank IS/Tn - - 1027642..1027818 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T263415 WP_000971655.1 NZ_CP110201:c1028418-1027891 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT263415 WP_000855692.1 NZ_CP110201:c1028705-1028415 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References