270767

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1025439..1026253 Replicon chromosome
Accession NZ_CP117357
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM096

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag PQQ15_RS04985 Protein ID WP_000971655.1
Coordinates 1025439..1025966 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag PQQ15_RS04990 Protein ID WP_000855692.1
Coordinates 1025963..1026253 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ15_RS04965 (1020739) 1020739..1023306 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
PQQ15_RS04970 (1023465) 1023465..1023986 + 522 WP_000858988.1 hypothetical protein -
PQQ15_RS04975 (1024158) 1024158..1024814 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQQ15_RS04980 (1025161) 1025161..1025366 + 206 Protein_976 IS5/IS1182 family transposase -
PQQ15_RS04985 (1025439) 1025439..1025966 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
PQQ15_RS04990 (1025963) 1025963..1026253 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
PQQ15_RS04995 (1026523) 1026523..1026701 - 179 Protein_979 IS3 family transposase -
PQQ15_RS05000 (1026942) 1026942..1027268 + 327 WP_000393302.1 hypothetical protein -
PQQ15_RS05005 (1027541) 1027541..1027888 - 348 WP_001669174.1 DUF1493 family protein -
PQQ15_RS05010 (1027873) 1027873..1028322 - 450 WP_000381610.1 membrane protein -
PQQ15_RS05015 (1028753) 1028753..1029196 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQQ15_RS05020 (1029653) 1029653..1030303 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1025190..1035616 10426
flank IS/Tn - - 1025190..1025366 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T270767 WP_000971655.1 NZ_CP117357:c1025966-1025439 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT270767 WP_000855692.1 NZ_CP117357:c1026253-1025963 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References