233574

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 995693..996507 Replicon chromosome
Accession NZ_CP091540
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag L5Z03_RS04755 Protein ID WP_000971655.1
Coordinates 995693..996220 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag L5Z03_RS04760 Protein ID WP_000855692.1
Coordinates 996217..996507 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z03_RS04735 (990993) 990993..993560 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
L5Z03_RS04740 (993719) 993719..994240 + 522 WP_000858988.1 hypothetical protein -
L5Z03_RS04745 (994412) 994412..995068 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
L5Z03_RS04750 (995415) 995415..995620 + 206 Protein_933 IS5/IS1182 family transposase -
L5Z03_RS04755 (995693) 995693..996220 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
L5Z03_RS04760 (996217) 996217..996507 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
L5Z03_RS04765 (996777) 996777..996955 - 179 Protein_936 IS3 family transposase -
L5Z03_RS04770 (997196) 997196..997522 + 327 WP_000393302.1 hypothetical protein -
L5Z03_RS04775 (997795) 997795..998142 - 348 WP_001669174.1 DUF1493 family protein -
L5Z03_RS04780 (998127) 998127..998576 - 450 WP_000381610.1 membrane protein -
L5Z03_RS04785 (999007) 999007..999450 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
L5Z03_RS04790 (999907) 999907..1000557 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 995444..995620 176
inside Genomic island - invH / invF / invG / invE / invA / invB 995444..1005870 10426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233574 WP_000971655.1 NZ_CP091540:c996220-995693 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233574 NZ_HG994850:2249161-2249263 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233574 WP_000855692.1 NZ_CP091540:c996507-996217 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233574 NZ_HG994850:c2249301-2249033 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References