Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1108721..1109535 Replicon chromosome
Accession NZ_AP023289
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3837

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag K5612_RS05375 Protein ID WP_000971655.1
Coordinates 1108721..1109248 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag K5612_RS05380 Protein ID WP_000855692.1
Coordinates 1109245..1109535 (-) Length 97 a.a.

Genomic Context

K5612_RS05360K5612_RS05370K5612_RS05390K5612_RS05410K5612_RS05355K5612_RS05365K5612_RS05375K5612_RS05380K5612_RS05385K5612_RS05395K5612_RS05400K5612_RS05405
Location: 1106747..1107268 (522 bp)
Type: Others
Protein ID: WP_000858988.1
Location: 1108443..1108648 (206 bp)
Type: Others
Protein ID: Protein_1057
Location: 1110224..1110550 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 1112935..1113585 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 1104021..1106588 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 1107440..1108096 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 1108721..1109248 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 1109245..1109535 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 1109805..1109983 (179 bp)
Type: Others
Protein ID: Protein_1060
Location: 1110823..1111170 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 1111155..1111604 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 1112035..1112478 (444 bp)
Type: Others
Protein ID: WP_000715092.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K5612_RS05355 (1104021)1104021..1106588-2568WP_001005807.1DNA mismatch repair protein MutS-
K5612_RS05360 (1106747)1106747..1107268+522WP_000858988.1hypothetical protein-
K5612_RS05365 (1107440)1107440..1108096-657WP_000420452.1protein-serine/threonine phosphatase-
K5612_RS05370 (1108443)1108443..1108648+206Protein_1057IS5/IS1182 family transposase-
K5612_RS05375 (1108721)1108721..1109248-528WP_000971655.1GNAT family N-acetyltransferaseToxin
K5612_RS05380 (1109245)1109245..1109535-291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
K5612_RS05385 (1109805)1109805..1109983-179Protein_1060IS3 family transposase-
K5612_RS05390 (1110224)1110224..1110550+327WP_000393302.1hypothetical protein-
K5612_RS05395 (1110823)1110823..1111170-348WP_001669174.1DUF1493 family protein-
K5612_RS05400 (1111155)1111155..1111604-450WP_000381610.1membrane protein-
K5612_RS05405 (1112035)1112035..1112478-444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
K5612_RS05410 (1112935)1112935..1113585+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB1108472..111889810426
flankIS/Tn--1108472..1108648176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T37198 WP_000971655.1 NZ_AP023289:c1109248-1108721 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T37198 NZ_AP023289:c1109248-1108721 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT37198 WP_000855692.1 NZ_AP023289:c1109535-1109245 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT37198 NZ_AP023289:c1109535-1109245 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References