250932

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3499662..3500476 Replicon chromosome
Accession NZ_CP100666
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R18.1630

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NL709_RS17150 Protein ID WP_000971655.1
Coordinates 3499949..3500476 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NL709_RS17145 Protein ID WP_000855694.1
Coordinates 3499662..3499952 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL709_RS17125 (3495565) 3495565..3497253 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
NL709_RS17130 (3497250) 3497250..3497900 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
NL709_RS17135 (3498356) 3498356..3498799 + 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NL709_RS17140 (3499203) 3499203..3499392 + 190 Protein_3340 IS3 family transposase -
NL709_RS17145 (3499662) 3499662..3499952 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NL709_RS17150 (3499949) 3499949..3500476 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NL709_RS17155 (3500549) 3500549..3500754 - 206 Protein_3343 IS5/IS1182 family transposase -
NL709_RS17160 (3501113) 3501113..3501769 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
NL709_RS17165 (3502014) 3502014..3502508 - 495 WP_000424949.1 hypothetical protein -
NL709_RS17170 (3502535) 3502535..3503203 - 669 WP_000445914.1 hypothetical protein -
NL709_RS17175 (3503789) 3503789..3504187 - 399 Protein_3347 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3500549..3500725 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T250932 WP_000971655.1 NZ_CP100666:3499949-3500476 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT250932 WP_000855694.1 NZ_CP100666:3499662-3499952 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References