270050

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3715059..3715873 Replicon chromosome
Accession NZ_CP117184
Organism Salmonella enterica subsp. enterica strain 123

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag PQ453_RS18455 Protein ID WP_000971655.1
Coordinates 3715346..3715873 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag PQ453_RS18450 Protein ID WP_000855692.1
Coordinates 3715059..3715349 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ453_RS18420 (3711009) 3711009..3711659 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
PQ453_RS18425 (3712116) 3712116..3712559 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQ453_RS18430 (3712990) 3712990..3713439 + 450 WP_000381610.1 membrane protein -
PQ453_RS18435 (3713424) 3713424..3713771 + 348 WP_001669174.1 DUF1493 family protein -
PQ453_RS18440 (3714044) 3714044..3714370 - 327 WP_000393302.1 hypothetical protein -
PQ453_RS18445 (3714611) 3714611..3714789 + 179 Protein_3598 IS3 family transposase -
PQ453_RS18450 (3715059) 3715059..3715349 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
PQ453_RS18455 (3715346) 3715346..3715873 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
PQ453_RS18460 (3715946) 3715946..3716151 - 206 Protein_3601 IS5/IS1182 family transposase -
PQ453_RS18465 (3716498) 3716498..3717154 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQ453_RS18470 (3717326) 3717326..3717847 - 522 WP_000858988.1 hypothetical protein -
PQ453_RS18475 (3718006) 3718006..3720573 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3715946..3716122 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T270050 WP_000971655.1 NZ_CP117184:3715346-3715873 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT270050 WP_000855692.1 NZ_CP117184:3715059-3715349 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References