146362

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1029272..1030086 Replicon chromosome
Accession NZ_CP047525
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11077

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag DXN14_RS04960 Protein ID WP_000971655.1
Coordinates 1029272..1029799 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag DXN14_RS04965 Protein ID WP_000855692.1
Coordinates 1029796..1030086 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN14_RS04940 (1024572) 1024572..1027139 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
DXN14_RS04945 (1027298) 1027298..1027819 + 522 WP_000858988.1 hypothetical protein -
DXN14_RS04950 (1027991) 1027991..1028647 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
DXN14_RS04955 (1028994) 1028994..1029199 + 206 Protein_975 IS5/IS1182 family transposase -
DXN14_RS04960 (1029272) 1029272..1029799 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
DXN14_RS04965 (1029796) 1029796..1030086 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
DXN14_RS04970 (1030356) 1030356..1030534 - 179 Protein_978 IS3 family transposase -
DXN14_RS04975 (1030775) 1030775..1031101 + 327 WP_000393302.1 hypothetical protein -
DXN14_RS04980 (1031374) 1031374..1031721 - 348 WP_001669174.1 DUF1493 family protein -
DXN14_RS04985 (1031706) 1031706..1032155 - 450 WP_000381610.1 membrane protein -
DXN14_RS04990 (1032586) 1032586..1033029 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
DXN14_RS04995 (1033486) 1033486..1034136 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1029023..1039449 10426
flank IS/Tn - - 1029023..1029199 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T146362 WP_000971655.1 NZ_CP047525:c1029799-1029272 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T146362 NZ_CP062744:283379-283486 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT146362 WP_000855692.1 NZ_CP047525:c1030086-1029796 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT146362 NZ_CP062744:c283331-283265 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References