Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1056084..1056898 Replicon chromosome
Accession NZ_CP090930
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.2430

Toxin (Protein)


Gene name TacT3 Uniprot ID B5F3Y4
Locus tag L1L23_RS05165 Protein ID WP_000971656.1
Coordinates 1056084..1056611 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag L1L23_RS05170 Protein ID WP_000855694.1
Coordinates 1056608..1056898 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1L23_RS05135 (1052384) 1052384..1052805 + 422 Protein_1008 cytoplasmic protein -
L1L23_RS05140 (1052973) 1052973..1053212 + 240 Protein_1009 hypothetical protein -
L1L23_RS05145 (1053369) 1053369..1054037 + 669 WP_000445914.1 hypothetical protein -
L1L23_RS05150 (1054064) 1054064..1054558 + 495 WP_000424943.1 hypothetical protein -
L1L23_RS05155 (1054803) 1054803..1055459 - 657 WP_000420449.1 protein-serine/threonine phosphatase -
L1L23_RS05160 (1055809) 1055809..1056011 + 203 Protein_1013 IS5/IS1182 family transposase -
L1L23_RS05165 (1056084) 1056084..1056611 - 528 WP_000971656.1 GNAT family N-acetyltransferase Toxin
L1L23_RS05170 (1056608) 1056608..1056898 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
L1L23_RS05175 (1057491) 1057491..1057817 + 327 WP_000393296.1 hypothetical protein -
L1L23_RS05180 (1058090) 1058090..1058437 - 348 WP_001555786.1 DUF1493 family protein -
L1L23_RS05185 (1058422) 1058422..1058871 - 450 WP_000381619.1 hypothetical protein -
L1L23_RS05190 (1059303) 1059303..1059746 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
L1L23_RS05195 (1060202) 1060202..1060852 + 651 WP_001747511.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1055835..1056011 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19156.98 Da        Isoelectric Point: 9.6420

>T232166 WP_000971656.1 NZ_CP090930:c1056611-1056084 [Salmonella enterica subsp. enterica serovar Agona]
MMFTDWHEAAIGKTHNRMNFDCGNADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHSFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLDRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T232166 NZ_CP127273:2304039-2304449 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT232166 WP_000855694.1 NZ_CP090930:c1056898-1056608 [Salmonella enterica subsp. enterica serovar Agona]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT232166 NZ_CP127273:2303813-2304046 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3J3UPI2

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References