Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1056084..1056898 | Replicon | chromosome |
| Accession | NZ_CP090930 | ||
| Organism | Salmonella enterica subsp. enterica serovar Agona strain R21.2430 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | B5F3Y4 |
| Locus tag | L1L23_RS05165 | Protein ID | WP_000971656.1 |
| Coordinates | 1056084..1056611 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | L1L23_RS05170 | Protein ID | WP_000855694.1 |
| Coordinates | 1056608..1056898 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1L23_RS05135 (1052384) | 1052384..1052805 | + | 422 | Protein_1008 | cytoplasmic protein | - |
| L1L23_RS05140 (1052973) | 1052973..1053212 | + | 240 | Protein_1009 | hypothetical protein | - |
| L1L23_RS05145 (1053369) | 1053369..1054037 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| L1L23_RS05150 (1054064) | 1054064..1054558 | + | 495 | WP_000424943.1 | hypothetical protein | - |
| L1L23_RS05155 (1054803) | 1054803..1055459 | - | 657 | WP_000420449.1 | protein-serine/threonine phosphatase | - |
| L1L23_RS05160 (1055809) | 1055809..1056011 | + | 203 | Protein_1013 | IS5/IS1182 family transposase | - |
| L1L23_RS05165 (1056084) | 1056084..1056611 | - | 528 | WP_000971656.1 | GNAT family N-acetyltransferase | Toxin |
| L1L23_RS05170 (1056608) | 1056608..1056898 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| L1L23_RS05175 (1057491) | 1057491..1057817 | + | 327 | WP_000393296.1 | hypothetical protein | - |
| L1L23_RS05180 (1058090) | 1058090..1058437 | - | 348 | WP_001555786.1 | DUF1493 family protein | - |
| L1L23_RS05185 (1058422) | 1058422..1058871 | - | 450 | WP_000381619.1 | hypothetical protein | - |
| L1L23_RS05190 (1059303) | 1059303..1059746 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| L1L23_RS05195 (1060202) | 1060202..1060852 | + | 651 | WP_001747511.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| flank | IS/Tn | - | - | 1055835..1056011 | 176 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19156.98 Da Isoelectric Point: 9.6420
>T232166 WP_000971656.1 NZ_CP090930:c1056611-1056084 [Salmonella enterica subsp. enterica serovar Agona]
MMFTDWHEAAIGKTHNRMNFDCGNADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHSFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLDRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGNADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHSFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLDRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T232166 NZ_CP127273:2304039-2304449 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT232166 WP_000855694.1 NZ_CP090930:c1056898-1056608 [Salmonella enterica subsp. enterica serovar Agona]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT232166 NZ_CP127273:2303813-2304046 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3J3UPI2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |