Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2984672..2985486 Replicon chromosome
Accession NZ_CP067091
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ER3625

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag JJB80_RS14570 Protein ID WP_000971655.1
Coordinates 2984959..2985486 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag JJB80_RS14565 Protein ID WP_000855692.1
Coordinates 2984672..2984962 (+) Length 97 a.a.

Genomic Context

JJB80_RS14540JJB80_RS14545JJB80_RS14550JJB80_RS14560JJB80_RS14565JJB80_RS14570JJB80_RS14580JJB80_RS14590JJB80_RS14535JJB80_RS14555JJB80_RS14575JJB80_RS14585
Location: 2981729..2982172 (444 bp)
Type: Others
Protein ID: WP_000715092.1
Location: 2982603..2983052 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 2983037..2983384 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 2984224..2984402 (179 bp)
Type: Others
Protein ID: Protein_2856
Location: 2984672..2984962 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 2984959..2985486 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 2986111..2986767 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 2987619..2990186 (2568 bp)
Type: Others
Protein ID: WP_210138824.1
Location: 2980622..2981272 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 2983657..2983983 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 2985559..2985764 (206 bp)
Type: Others
Protein ID: Protein_2859
Location: 2986939..2987460 (522 bp)
Type: Others
Protein ID: WP_000858988.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JJB80_RS14535 (2980622)2980622..2981272-651WP_001674874.1type III secretion system transcriptional activator InvF-
JJB80_RS14540 (2981729)2981729..2982172+444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
JJB80_RS14545 (2982603)2982603..2983052+450WP_000381610.1membrane protein-
JJB80_RS14550 (2983037)2983037..2983384+348WP_001669174.1DUF1493 family protein-
JJB80_RS14555 (2983657)2983657..2983983-327WP_000393302.1hypothetical protein-
JJB80_RS14560 (2984224)2984224..2984402+179Protein_2856IS3 family transposase-
JJB80_RS14565 (2984672)2984672..2984962+291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
JJB80_RS14570 (2984959)2984959..2985486+528WP_000971655.1GNAT family N-acetyltransferaseToxin
JJB80_RS14575 (2985559)2985559..2985764-206Protein_2859IS5/IS1182 family transposase-
JJB80_RS14580 (2986111)2986111..2986767+657WP_000420452.1protein-serine/threonine phosphatase-
JJB80_RS14585 (2986939)2986939..2987460-522WP_000858988.1hypothetical protein-
JJB80_RS14590 (2987619)2987619..2990186+2568WP_210138824.1DNA mismatch repair protein MutS-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invA / invA / invE / invG / invF / invH2975739..298676711028
flankIS/Tn--2985559..2985735176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T185724 WP_000971655.1 NZ_CP067091:2984959-2985486 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T185724 NZ_CP089011:127295-127765 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACTCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT185724 WP_000855692.1 NZ_CP067091:2984672-2984962 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT185724 NZ_CP089011:126855-127298 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCCAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACTTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

Loading, please wait
Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References