185724

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2984672..2985486 Replicon chromosome
Accession NZ_CP067091
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ER3625

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag JJB80_RS14570 Protein ID WP_000971655.1
Coordinates 2984959..2985486 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag JJB80_RS14565 Protein ID WP_000855692.1
Coordinates 2984672..2984962 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB80_RS14535 (2980622) 2980622..2981272 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
JJB80_RS14540 (2981729) 2981729..2982172 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
JJB80_RS14545 (2982603) 2982603..2983052 + 450 WP_000381610.1 membrane protein -
JJB80_RS14550 (2983037) 2983037..2983384 + 348 WP_001669174.1 DUF1493 family protein -
JJB80_RS14555 (2983657) 2983657..2983983 - 327 WP_000393302.1 hypothetical protein -
JJB80_RS14560 (2984224) 2984224..2984402 + 179 Protein_2856 IS3 family transposase -
JJB80_RS14565 (2984672) 2984672..2984962 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
JJB80_RS14570 (2984959) 2984959..2985486 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
JJB80_RS14575 (2985559) 2985559..2985764 - 206 Protein_2859 IS5/IS1182 family transposase -
JJB80_RS14580 (2986111) 2986111..2986767 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
JJB80_RS14585 (2986939) 2986939..2987460 - 522 WP_000858988.1 hypothetical protein -
JJB80_RS14590 (2987619) 2987619..2990186 + 2568 WP_210138824.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invA / invA / invE / invG / invF / invH 2975739..2986767 11028
flank IS/Tn - - 2985559..2985735 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T185724 WP_000971655.1 NZ_CP067091:2984959-2985486 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T185724 NZ_CP089011:127295-127765 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACTCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT185724 WP_000855692.1 NZ_CP067091:2984672-2984962 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT185724 NZ_CP089011:126855-127298 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCCAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACTTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References