282714

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2610708..2611522 Replicon chromosome
Accession NZ_CP126166
Organism Salmonella enterica subsp. enterica strain CRSE-01

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NED09_RS12495 Protein ID WP_000971655.1
Coordinates 2610708..2611235 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NED09_RS12500 Protein ID WP_000855694.1
Coordinates 2611232..2611522 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NED09_RS12470 (2606997) 2606997..2607395 + 399 Protein_2414 cytoplasmic protein -
NED09_RS12475 (2607981) 2607981..2608649 + 669 WP_000445914.1 hypothetical protein -
NED09_RS12480 (2608676) 2608676..2609170 + 495 WP_000424949.1 hypothetical protein -
NED09_RS12485 (2609415) 2609415..2610071 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NED09_RS12490 (2610430) 2610430..2610635 + 206 Protein_2418 IS5/IS1182 family transposase -
NED09_RS12495 (2610708) 2610708..2611235 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NED09_RS12500 (2611232) 2611232..2611522 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NED09_RS12505 (2611792) 2611792..2611981 - 190 Protein_2421 IS3 family transposase -
NED09_RS12510 (2612385) 2612385..2612828 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NED09_RS12515 (2613284) 2613284..2613934 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
NED09_RS12520 (2613931) 2613931..2615619 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2610459..2610635 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T282714 WP_000971655.1 NZ_CP126166:c2611235-2610708 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT282714 WP_000855694.1 NZ_CP126166:c2611522-2611232 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References