222054

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4502825..4503639 Replicon chromosome
Accession NZ_CP085822
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF58_RS21895 Protein ID WP_000971655.1
Coordinates 4502825..4503352 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF58_RS21900 Protein ID WP_000855694.1
Coordinates 4503349..4503639 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF58_RS21870 (4499114) 4499114..4499512 + 399 Protein_4256 cytoplasmic protein -
LJF58_RS21875 (4500098) 4500098..4500766 + 669 WP_000445914.1 hypothetical protein -
LJF58_RS21880 (4500793) 4500793..4501287 + 495 WP_000424949.1 hypothetical protein -
LJF58_RS21885 (4501532) 4501532..4502188 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF58_RS21890 (4502547) 4502547..4502752 + 206 Protein_4260 IS5/IS1182 family transposase -
LJF58_RS21895 (4502825) 4502825..4503352 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF58_RS21900 (4503349) 4503349..4503639 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF58_RS21905 (4503909) 4503909..4504098 - 190 Protein_4263 IS3 family transposase -
LJF58_RS21910 (4504502) 4504502..4504945 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF58_RS21915 (4505401) 4505401..4506051 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF58_RS21920 (4506048) 4506048..4507736 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4502576..4502752 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T222054 WP_000971655.1 NZ_CP085822:c4503352-4502825 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T222054 NZ_CP117668:c2884460-2884308 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT222054 WP_000855694.1 NZ_CP085822:c4503639-4503349 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT222054 NZ_CP117668:2884517-2884565 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References