222551

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028029..1028843 Replicon chromosome
Accession NZ_CP086118
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S34

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LLY43_RS04945 Protein ID WP_000971655.1
Coordinates 1028029..1028556 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag LLY43_RS04950 Protein ID WP_000855692.1
Coordinates 1028553..1028843 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLY43_RS04925 (1023329) 1023329..1025896 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
LLY43_RS04930 (1026055) 1026055..1026576 + 522 WP_000858988.1 hypothetical protein -
LLY43_RS04935 (1026748) 1026748..1027404 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LLY43_RS04940 (1027751) 1027751..1027956 + 206 Protein_970 IS5/IS1182 family transposase -
LLY43_RS04945 (1028029) 1028029..1028556 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LLY43_RS04950 (1028553) 1028553..1028843 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
LLY43_RS04955 (1029113) 1029113..1029291 - 179 Protein_973 IS3 family transposase -
LLY43_RS04960 (1029532) 1029532..1029858 + 327 WP_000393302.1 hypothetical protein -
LLY43_RS04965 (1030131) 1030131..1030478 - 348 WP_001669174.1 DUF1493 family protein -
LLY43_RS04970 (1030463) 1030463..1030912 - 450 WP_000381610.1 membrane protein -
LLY43_RS04975 (1031343) 1031343..1031786 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LLY43_RS04980 (1032243) 1032243..1032893 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1027780..1038206 10426
flank IS/Tn - - 1027780..1027956 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T222551 WP_000971655.1 NZ_CP086118:c1028556-1028029 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T222551 NZ_CP117961:c11377-11036 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT222551 WP_000855692.1 NZ_CP086118:c1028843-1028553 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT222551 NZ_CP117961:c11715-11398 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References