Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 985307..986121 Replicon chromosome
Accession NZ_CP088136
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SCPM-O-B-4515

Toxin (Protein)


Gene name TacT3 Uniprot ID B5RDM7
Locus tag LRM91_RS04735 Protein ID WP_000971654.1
Coordinates 985307..985834 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LRM91_RS04740 Protein ID WP_000855694.1
Coordinates 985831..986121 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM91_RS04710 (981596) 981596..981994 + 399 Protein_923 cytoplasmic protein -
LRM91_RS04715 (982580) 982580..983248 + 669 WP_000445914.1 hypothetical protein -
LRM91_RS04720 (983275) 983275..983769 + 495 WP_000424949.1 hypothetical protein -
LRM91_RS04725 (984014) 984014..984670 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LRM91_RS04730 (985029) 985029..985234 + 206 Protein_927 IS5/IS1182 family transposase -
LRM91_RS04735 (985307) 985307..985834 - 528 WP_000971654.1 GNAT family N-acetyltransferase Toxin
LRM91_RS04740 (985831) 985831..986121 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LRM91_RS04745 (986391) 986391..986580 - 190 Protein_930 IS3 family transposase -
LRM91_RS04750 (986984) 986984..987427 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LRM91_RS04755 (987883) 987883..988533 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LRM91_RS04760 (988530) 988530..990218 + 1689 WP_249895505.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 985058..985234 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-147)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19041.85 Da        Isoelectric Point: 9.6420

>T226768 WP_000971654.1 NZ_CP088136:c985834-985307 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQACDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T226768 NZ_CP122624:22337-22585 [Escherichia coli]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT226768 WP_000855694.1 NZ_CP088136:c986121-985831 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT226768 NZ_CP122624:22582-22929 [Escherichia coli]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y9PNF0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References