Detailed information of TA system TA207641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1090567..1091381
• Replicon: chromosome
• Accession: NZ_CP077711
• Organism: Salmonella enterica subsp. enterica strain CFSAN058606

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A5V4GVG3
• Locus tag: DAX63_RS05280
• Protein ID: WP_023240269.1
• Coordinates: 1090567..1091094 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: DAX63_RS05285
• Protein ID: WP_000855694.1
• Coordinates: 1091091..1091381 (-)
• Length: 97 a.a.

Genomic Context

Location: 1088495..1089016 (522 bp)
Type: Others
Protein ID: WP_000858989.1

Location: 1090070..1090494 (425 bp)
Type: Others
Protein ID: Protein_1037

Location: 1093142..1093792 (651 bp)
Type: Others
Protein ID: WP_001674874.1

Location: 1093789..1095477 (1689 bp)
Type: Others
Protein ID: WP_000848101.1

Location: 1085769..1088336 (2568 bp)
Type: Others
Protein ID: WP_108429726.1

Location: 1089188..1089844 (657 bp)
Type: Others
Protein ID: WP_000420447.1

Location: 1090567..1091094 (528 bp)
Type: Toxin
Protein ID: WP_023240269.1

Location: 1091091..1091381 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1

Location: 1091650..1091839 (190 bp)
Type: Others
Protein ID: Protein_1040

Location: 1092243..1092686 (444 bp)
Type: Others
Protein ID: WP_000715096.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX63_RS05260 (1085769)	1085769..1088336	-	2568	WP_108429726.1	DNA mismatch repair protein MutS	-
DAX63_RS05265 (1088495)	1088495..1089016	+	522	WP_000858989.1	hypothetical protein	-
DAX63_RS05270 (1089188)	1089188..1089844	-	657	WP_000420447.1	protein-serine/threonine phosphatase	-
DAX63_RS05275 (1090070)	1090070..1090494	+	425	Protein_1037	transposase	-
DAX63_RS05280 (1090567)	1090567..1091094	-	528	WP_023240269.1	GNAT family N-acetyltransferase	Toxin
DAX63_RS05285 (1091091)	1091091..1091381	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
DAX63_RS05290 (1091650)	1091650..1091839	-	190	Protein_1040	IS3 family transposase	-
DAX63_RS05295 (1092243)	1092243..1092686	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
DAX63_RS05300 (1093142)	1093142..1093792	+	651	WP_001674874.1	type III secretion system transcriptional activator InvF	-
DAX63_RS05305 (1093789)	1093789..1095477	+	1689	WP_000848101.1	type III secretion system outer membrane ring protein InvG	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1090318..1099105	8787
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 IS/Tn TA025955 3070795..3070971 0.007 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S IS/Tn TA026055 3068456..3068632 0.007 View UFRD01000002 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 IS/Tn TA010052 4599654..4599830 0.007	flank	IS/Tn	-	-	1090318..1090494	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-147)

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19087.92 Da
• Isoelectric Point: 9.8230

>T207641 WP_023240269.1 NZ_CP077711:c1091094-1090567 [Salmonella enterica subsp. enterica]
MMFTDWHEAATGKTHNRMNFDCGDADLNQFLQRHARKNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVSGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T207641 NZ_CP103465:949877-950284 [Escherichia coli O25b:H4-ST131]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT207641 WP_000855694.1 NZ_CP077711:c1091381-1091091 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT207641 NZ_CP103465:949630-949896 [Escherichia coli O25b:H4-ST131]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Structures

Toxin

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• AlphaFold DB: A0A5V4GVG3

Antitoxin

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• AlphaFold DB: A0A3V8SJE7