Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 996165..996979 Replicon chromosome
Accession NZ_AP023300
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4445

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag K5630_RS04750 Protein ID WP_000971655.1
Coordinates 996165..996692 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag K5630_RS04755 Protein ID WP_000855692.1
Coordinates 996689..996979 (-) Length 97 a.a.

Genomic Context

K5630_RS04735K5630_RS04745K5630_RS04765K5630_RS04785K5630_RS04730K5630_RS04740K5630_RS04750K5630_RS04755K5630_RS04760K5630_RS04770K5630_RS04775K5630_RS04780
Location: 994191..994712 (522 bp)
Type: Others
Protein ID: WP_000858988.1
Location: 995887..996092 (206 bp)
Type: Others
Protein ID: Protein_931
Location: 997668..997994 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 1000379..1001029 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 991465..994032 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 994884..995540 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 996165..996692 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 996689..996979 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 997249..997427 (179 bp)
Type: Others
Protein ID: Protein_934
Location: 998267..998614 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 998599..999048 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 999479..999922 (444 bp)
Type: Others
Protein ID: WP_000715092.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K5630_RS04730 (991465)991465..994032-2568WP_001005807.1DNA mismatch repair protein MutS-
K5630_RS04735 (994191)994191..994712+522WP_000858988.1hypothetical protein-
K5630_RS04740 (994884)994884..995540-657WP_000420452.1protein-serine/threonine phosphatase-
K5630_RS04745 (995887)995887..996092+206Protein_931IS5/IS1182 family transposase-
K5630_RS04750 (996165)996165..996692-528WP_000971655.1GNAT family N-acetyltransferaseToxin
K5630_RS04755 (996689)996689..996979-291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
K5630_RS04760 (997249)997249..997427-179Protein_934IS3 family transposase-
K5630_RS04765 (997668)997668..997994+327WP_000393302.1hypothetical protein-
K5630_RS04770 (998267)998267..998614-348WP_001669174.1DUF1493 family protein-
K5630_RS04775 (998599)998599..999048-450WP_000381610.1membrane protein-
K5630_RS04780 (999479)999479..999922-444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
K5630_RS04785 (1000379)1000379..1001029+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB995916..100634210426
flankIS/Tn--995916..996092176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T37343 WP_000971655.1 NZ_AP023300:c996692-996165 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T37343 NZ_AP023300:c996692-996165 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT37343 WP_000855692.1 NZ_AP023300:c996979-996689 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT37343 NZ_AP023300:c996979-996689 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References