Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028041..1028855 Replicon chromosome
Accession NZ_AP023290
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3844

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag K5615_RS04940 Protein ID WP_000971655.1
Coordinates 1028041..1028568 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag K5615_RS04945 Protein ID WP_000855692.1
Coordinates 1028565..1028855 (-) Length 97 a.a.

Genomic Context

K5615_RS04925K5615_RS04935K5615_RS04955K5615_RS04975K5615_RS04920K5615_RS04930K5615_RS04940K5615_RS04945K5615_RS04950K5615_RS04960K5615_RS04965K5615_RS04970
Location: 1026067..1026588 (522 bp)
Type: Others
Protein ID: WP_000858988.1
Location: 1027763..1027968 (206 bp)
Type: Others
Protein ID: Protein_970
Location: 1029544..1029870 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 1032255..1032905 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 1023341..1025908 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 1026760..1027416 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 1028041..1028568 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 1028565..1028855 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 1029125..1029303 (179 bp)
Type: Others
Protein ID: Protein_973
Location: 1030143..1030490 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 1030475..1030924 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 1031355..1031798 (444 bp)
Type: Others
Protein ID: WP_000715092.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K5615_RS04920 (1023341)1023341..1025908-2568WP_001005807.1DNA mismatch repair protein MutS-
K5615_RS04925 (1026067)1026067..1026588+522WP_000858988.1hypothetical protein-
K5615_RS04930 (1026760)1026760..1027416-657WP_000420452.1protein-serine/threonine phosphatase-
K5615_RS04935 (1027763)1027763..1027968+206Protein_970IS5/IS1182 family transposase-
K5615_RS04940 (1028041)1028041..1028568-528WP_000971655.1GNAT family N-acetyltransferaseToxin
K5615_RS04945 (1028565)1028565..1028855-291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
K5615_RS04950 (1029125)1029125..1029303-179Protein_973IS3 family transposase-
K5615_RS04955 (1029544)1029544..1029870+327WP_000393302.1hypothetical protein-
K5615_RS04960 (1030143)1030143..1030490-348WP_001669174.1DUF1493 family protein-
K5615_RS04965 (1030475)1030475..1030924-450WP_000381610.1membrane protein-
K5615_RS04970 (1031355)1031355..1031798-444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
K5615_RS04975 (1032255)1032255..1032905+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB1027792..103821810426
flankIS/Tn--1027792..1027968176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T37222 WP_000971655.1 NZ_AP023290:c1028568-1028041 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T37222 NZ_AP023290:c1028568-1028041 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT37222 WP_000855692.1 NZ_AP023290:c1028855-1028565 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT37222 NZ_AP023290:c1028855-1028565 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References