Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3868657..3869471 Replicon chromosome
Accession NZ_CP091558
Organism Salmonella enterica strain 418

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag INN79_RS19125 Protein ID WP_000971655.1
Coordinates 3868657..3869184 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag INN79_RS19130 Protein ID WP_000855692.1
Coordinates 3869181..3869471 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN79_RS19105 (3863957) 3863957..3866524 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
INN79_RS19110 (3866683) 3866683..3867204 + 522 WP_000858988.1 hypothetical protein -
INN79_RS19115 (3867376) 3867376..3868032 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
INN79_RS19120 (3868379) 3868379..3868584 + 206 Protein_3738 IS5/IS1182 family transposase -
INN79_RS19125 (3868657) 3868657..3869184 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
INN79_RS19130 (3869181) 3869181..3869471 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
INN79_RS19135 (3869741) 3869741..3869919 - 179 Protein_3741 IS3 family transposase -
INN79_RS19140 (3870160) 3870160..3870486 + 327 WP_000393302.1 hypothetical protein -
INN79_RS19145 (3870759) 3870759..3871106 - 348 WP_001669174.1 DUF1493 family protein -
INN79_RS19150 (3871091) 3871091..3871540 - 450 WP_000381610.1 membrane protein -
INN79_RS19155 (3871971) 3871971..3872414 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
INN79_RS19160 (3872871) 3872871..3873521 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 3868408..3878834 10426
flank IS/Tn - - 3868408..3868584 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233741 WP_000971655.1 NZ_CP091558:c3869184-3868657 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233741 NZ_LN626917:c2560487-2560380 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233741 WP_000855692.1 NZ_CP091558:c3869471-3869181 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233741 NZ_LN626917:2560303-2560363 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References