Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028016..1028830 Replicon chromosome
Accession NZ_CP077668
Organism Salmonella enterica strain SP

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag KTP12_RS04960 Protein ID WP_000971655.1
Coordinates 1028016..1028543 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag KTP12_RS04965 Protein ID WP_000855692.1
Coordinates 1028540..1028830 (-) Length 97 a.a.

Genomic Context

KTP12_RS04945KTP12_RS04955KTP12_RS04975KTP12_RS04995KTP12_RS04940KTP12_RS04950KTP12_RS04960KTP12_RS04965KTP12_RS04970KTP12_RS04980KTP12_RS04985KTP12_RS04990
Location: 1026042..1026563 (522 bp)
Type: Others
Protein ID: WP_000858988.1
Location: 1027738..1027943 (206 bp)
Type: Others
Protein ID: Protein_972
Location: 1029519..1029845 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 1032230..1032880 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 1023316..1025883 (2568 bp)
Type: Others
Protein ID: WP_023139379.1
Location: 1026735..1027391 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 1028016..1028543 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 1028540..1028830 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 1029100..1029278 (179 bp)
Type: Others
Protein ID: Protein_975
Location: 1030118..1030465 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 1030450..1030899 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 1031330..1031773 (444 bp)
Type: Others
Protein ID: WP_000715092.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KTP12_RS04940 (1023316)1023316..1025883-2568WP_023139379.1DNA mismatch repair protein MutS-
KTP12_RS04945 (1026042)1026042..1026563+522WP_000858988.1hypothetical protein-
KTP12_RS04950 (1026735)1026735..1027391-657WP_000420452.1protein-serine/threonine phosphatase-
KTP12_RS04955 (1027738)1027738..1027943+206Protein_972IS5/IS1182 family transposase-
KTP12_RS04960 (1028016)1028016..1028543-528WP_000971655.1GNAT family N-acetyltransferaseToxin
KTP12_RS04965 (1028540)1028540..1028830-291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
KTP12_RS04970 (1029100)1029100..1029278-179Protein_975IS3 family transposase-
KTP12_RS04975 (1029519)1029519..1029845+327WP_000393302.1hypothetical protein-
KTP12_RS04980 (1030118)1030118..1030465-348WP_001669174.1DUF1493 family protein-
KTP12_RS04985 (1030450)1030450..1030899-450WP_000381610.1membrane protein-
KTP12_RS04990 (1031330)1031330..1031773-444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
KTP12_RS04995 (1032230)1032230..1032880+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB1027767..103819310426
flankIS/Tn--1027767..1027943176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T207382 WP_000971655.1 NZ_CP077668:c1028543-1028016 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T207382 NZ_CP102972:c1897931-1897779 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT207382 WP_000855692.1 NZ_CP077668:c1028830-1028540 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT207382 NZ_CP102972:c1898555-1897956 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References