207382

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028016..1028830 Replicon chromosome
Accession NZ_CP077668
Organism Salmonella enterica strain SP

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag KTP12_RS04960 Protein ID WP_000971655.1
Coordinates 1028016..1028543 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag KTP12_RS04965 Protein ID WP_000855692.1
Coordinates 1028540..1028830 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP12_RS04940 (1023316) 1023316..1025883 - 2568 WP_023139379.1 DNA mismatch repair protein MutS -
KTP12_RS04945 (1026042) 1026042..1026563 + 522 WP_000858988.1 hypothetical protein -
KTP12_RS04950 (1026735) 1026735..1027391 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
KTP12_RS04955 (1027738) 1027738..1027943 + 206 Protein_972 IS5/IS1182 family transposase -
KTP12_RS04960 (1028016) 1028016..1028543 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
KTP12_RS04965 (1028540) 1028540..1028830 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
KTP12_RS04970 (1029100) 1029100..1029278 - 179 Protein_975 IS3 family transposase -
KTP12_RS04975 (1029519) 1029519..1029845 + 327 WP_000393302.1 hypothetical protein -
KTP12_RS04980 (1030118) 1030118..1030465 - 348 WP_001669174.1 DUF1493 family protein -
KTP12_RS04985 (1030450) 1030450..1030899 - 450 WP_000381610.1 membrane protein -
KTP12_RS04990 (1031330) 1031330..1031773 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KTP12_RS04995 (1032230) 1032230..1032880 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1027767..1038193 10426
flank IS/Tn - - 1027767..1027943 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T207382 WP_000971655.1 NZ_CP077668:c1028543-1028016 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T207382 NZ_CP102972:c1897931-1897779 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT207382 WP_000855692.1 NZ_CP077668:c1028830-1028540 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT207382 NZ_CP102972:c1898555-1897956 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References