233664

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3714377..3715191 Replicon chromosome
Accession NZ_CP091547
Organism Salmonella enterica strain 1559

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag L4413_RS18440 Protein ID WP_000971655.1
Coordinates 3714664..3715191 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag L4413_RS18435 Protein ID WP_000855692.1
Coordinates 3714377..3714667 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4413_RS18405 (3710327) 3710327..3710977 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
L4413_RS18410 (3711434) 3711434..3711877 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
L4413_RS18415 (3712308) 3712308..3712757 + 450 WP_000381610.1 membrane protein -
L4413_RS18420 (3712742) 3712742..3713089 + 348 WP_001669174.1 DUF1493 family protein -
L4413_RS18425 (3713362) 3713362..3713688 - 327 WP_000393302.1 hypothetical protein -
L4413_RS18430 (3713929) 3713929..3714107 + 179 Protein_3597 IS3 family transposase -
L4413_RS18435 (3714377) 3714377..3714667 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
L4413_RS18440 (3714664) 3714664..3715191 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
L4413_RS18445 (3715264) 3715264..3715469 - 206 Protein_3600 IS5/IS1182 family transposase -
L4413_RS18450 (3715816) 3715816..3716472 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
L4413_RS18455 (3716644) 3716644..3717165 - 522 WP_000858988.1 hypothetical protein -
L4413_RS18460 (3717324) 3717324..3719891 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3715264..3715440 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233664 WP_000971655.1 NZ_CP091547:3714664-3715191 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233664 NZ_LM993812:c262893-262552 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233664 WP_000855692.1 NZ_CP091547:3714377-3714667 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233664 NZ_LM993812:c263231-262914 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References