Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3579412..3580226 Replicon chromosome
Accession NZ_CP085793
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Poochyena

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF61_RS17520 Protein ID WP_000971655.1
Coordinates 3579699..3580226 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF61_RS17515 Protein ID WP_000855694.1
Coordinates 3579412..3579702 (+) Length 97 a.a.

Genomic Context

LJF61_RS17505LJF61_RS17510LJF61_RS17515LJF61_RS17520LJF61_RS17530LJF61_RS17495LJF61_RS17500LJF61_RS17525LJF61_RS17535LJF61_RS17540LJF61_RS17545
Location: 3578106..3578549 (444 bp)
Type: Others
Protein ID: WP_000715097.1
Location: 3578953..3579142 (190 bp)
Type: Others
Protein ID: Protein_3410
Location: 3579412..3579702 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 3579699..3580226 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 3580863..3581519 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 3575315..3577003 (1689 bp)
Type: Others
Protein ID: WP_000848113.1
Location: 3577000..3577650 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 3580299..3580504 (206 bp)
Type: Others
Protein ID: Protein_3413
Location: 3581764..3582258 (495 bp)
Type: Others
Protein ID: WP_000424949.1
Location: 3582285..3582953 (669 bp)
Type: Others
Protein ID: WP_000445914.1
Location: 3583539..3583937 (399 bp)
Type: Others
Protein ID: Protein_3417
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF61_RS17495 (3575315)3575315..3577003-1689WP_000848113.1type III secretion system outer membrane ring protein InvG-
LJF61_RS17500 (3577000)3577000..3577650-651WP_001674874.1type III secretion system transcriptional activator InvF-
LJF61_RS17505 (3578106)3578106..3578549+444WP_000715097.1SPI-1 type III secretion system invasion lipoprotein InvH-
LJF61_RS17510 (3578953)3578953..3579142+190Protein_3410IS3 family transposase-
LJF61_RS17515 (3579412)3579412..3579702+291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
LJF61_RS17520 (3579699)3579699..3580226+528WP_000971655.1GNAT family N-acetyltransferaseToxin
LJF61_RS17525 (3580299)3580299..3580504-206Protein_3413IS5/IS1182 family transposase-
LJF61_RS17530 (3580863)3580863..3581519+657WP_000420452.1protein-serine/threonine phosphatase-
LJF61_RS17535 (3581764)3581764..3582258-495WP_000424949.1hypothetical protein-
LJF61_RS17540 (3582285)3582285..3582953-669WP_000445914.1hypothetical protein-
LJF61_RS17545 (3583539)3583539..3583937-399Protein_3417cytoplasmic protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--3580299..3580475176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221350 WP_000971655.1 NZ_CP085793:3579699-3580226 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221350 NZ_CP117382:188847-189332 [Salmonella enterica subsp. enterica serovar Uganda]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221350 WP_000855694.1 NZ_CP085793:3579412-3579702 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221350 NZ_CP117382:188572-188859 [Salmonella enterica subsp. enterica serovar Uganda]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References