Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1045564..1046378 Replicon chromosome
Accession NZ_AP023288
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3835

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag K5610_RS05070 Protein ID WP_000971655.1
Coordinates 1045564..1046091 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag K5610_RS05075 Protein ID WP_000855692.1
Coordinates 1046088..1046378 (-) Length 97 a.a.

Genomic Context

K5610_RS05055K5610_RS05065K5610_RS05085K5610_RS05105K5610_RS05050K5610_RS05060K5610_RS05070K5610_RS05075K5610_RS05080K5610_RS05090K5610_RS05095K5610_RS05100
Location: 1043590..1044111 (522 bp)
Type: Others
Protein ID: WP_000858988.1
Location: 1045286..1045491 (206 bp)
Type: Others
Protein ID: Protein_995
Location: 1047067..1047393 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 1049778..1050428 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 1040864..1043431 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 1044283..1044939 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 1045564..1046091 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 1046088..1046378 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 1046648..1046826 (179 bp)
Type: Others
Protein ID: Protein_998
Location: 1047666..1048013 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 1047998..1048447 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 1048878..1049321 (444 bp)
Type: Others
Protein ID: WP_000715092.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K5610_RS05050 (1040864)1040864..1043431-2568WP_001005807.1DNA mismatch repair protein MutS-
K5610_RS05055 (1043590)1043590..1044111+522WP_000858988.1hypothetical protein-
K5610_RS05060 (1044283)1044283..1044939-657WP_000420452.1protein-serine/threonine phosphatase-
K5610_RS05065 (1045286)1045286..1045491+206Protein_995IS5/IS1182 family transposase-
K5610_RS05070 (1045564)1045564..1046091-528WP_000971655.1GNAT family N-acetyltransferaseToxin
K5610_RS05075 (1046088)1046088..1046378-291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
K5610_RS05080 (1046648)1046648..1046826-179Protein_998IS3 family transposase-
K5610_RS05085 (1047067)1047067..1047393+327WP_000393302.1hypothetical protein-
K5610_RS05090 (1047666)1047666..1048013-348WP_001669174.1DUF1493 family protein-
K5610_RS05095 (1047998)1047998..1048447-450WP_000381610.1membrane protein-
K5610_RS05100 (1048878)1048878..1049321-444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
K5610_RS05105 (1049778)1049778..1050428+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB1045315..105574110426
flankIS/Tn--1045315..1045491176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T37174 WP_000971655.1 NZ_AP023288:c1046091-1045564 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T37174 NZ_AP023288:c1046091-1045564 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT37174 WP_000855692.1 NZ_AP023288:c1046378-1046088 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT37174 NZ_AP023288:c1046378-1046088 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

Loading, please wait
Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References